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HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
Nature genetics, 48 (2016), 3; 318-322. https://doi.org/10.1038/ng.3498
Sveinbjornsson, Gardar; Bulat Kardum, Ljiljana; Knežević, Jelena; ...

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Sveinbjornsson, G., Bulat Kardum, Lj. i Knežević, J. (2016). HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature genetics, 48. (3), 318-322. doi: 10.1038/ng.3498

Sveinbjornsson, Gardar, et al. "HLA class II sequence variants influence tuberculosis risk in populations of European ancestry." Nature genetics, vol. 48, br. 3, 2016, str. 318-322. https://doi.org/10.1038/ng.3498

Sveinbjornsson, Gardar, Ljiljana Bulat Kardum i Jelena Knežević. "HLA class II sequence variants influence tuberculosis risk in populations of European ancestry." Nature genetics 48, br. 3 (2016): 318-322. https://doi.org/10.1038/ng.3498

Sveinbjornsson, G., Bulat Kardum, Lj. i Knežević, J. (2016) 'HLA class II sequence variants influence tuberculosis risk in populations of European ancestry', Nature genetics, 48(3), str. 318-322. doi: 10.1038/ng.3498

Sveinbjornsson G, Bulat Kardum Lj, Knežević J. HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature genetics [Internet]. 2016. [pristupljeno 27.12.2024.];48(3):318-322. doi: 10.1038/ng.3498

G. Sveinbjornsson, Lj. Bulat Kardum i J. Knežević, "HLA class II sequence variants influence tuberculosis risk in populations of European ancestry", Nature genetics, vol. 48, br. 3, str. 318-322, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:906681. [Citirano: 27.12.2024.]

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Podaci o radu
Naslov (engleski)HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
AutorGardar Sveinbjornsson
AutorLjiljana Bulat Kardum
AutorJelena Knežević
Autor
...
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5 million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 million variants identified through whole-genome sequencing of 2, 636 Icelanders for association with tuberculosis (8, 162 cases and 277, 643 controls), pulmonary tuberculosis (PTB) and M. tuberculosis infection. We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): rs557011[T] (minor allele frequency (MAF) = 40.2%), associated with M. tuberculosis infection (odds ratio (OR) = 1.14, P = 3.1 × 10(-13)) and PTB (OR = 1.25, P = 5.8 × 10(-12)), and rs9271378[G] (MAF = 32.5%), associated with PTB (OR = 0.78, P = 2.5 × 10(-12))-both located between HLA-DQA1 and HLA-DRB1-and a missense variant encoding p.Ala210Thr in HLA-DQA1 (MAF = 19.1%, rs9272785), associated with M. tuberculosis infection (P = 9.3 × 10(-9), OR = 1.14). We replicated association of these variants with PTB in samples of European ancestry from Russia and Croatia (P < 5.9 × 10(-4)). These findings show that the HLA class II region contributes to genetic risk of tuberculosis, possibly through reduced presentation of protective M. tuberculosis antigens to T cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaNature genetics
Brojčani podacivol. 48, br. 3, str. 318-322
p-ISSN1061-4036
DOIhttps://doi.org/10.1038/ng.3498
URN:NBNurn:nbn:hr:184:906681
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/818514
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-21 17:57:18