prikaz prve stranice dokumenta HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
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Scientific paper - Original scientific paper
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
Nature genetics, 48 (2016), 3; 318-322. https://doi.org/10.1038/ng.3498
Sveinbjornsson, Gardar; Bulat Kardum, Ljiljana; Knežević, Jelena; ...

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Sveinbjornsson, G., Bulat Kardum, Lj. & Knežević, J. (2016). HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature genetics, 48. (3), 318-322. doi: 10.1038/ng.3498

Sveinbjornsson, Gardar, et al. "HLA class II sequence variants influence tuberculosis risk in populations of European ancestry." Nature genetics, vol. 48, no. 3, 2016, pp. 318-322. https://doi.org/10.1038/ng.3498

Sveinbjornsson, Gardar, Ljiljana Bulat Kardum and Jelena Knežević. "HLA class II sequence variants influence tuberculosis risk in populations of European ancestry." Nature genetics 48, no. 3 (2016): 318-322. https://doi.org/10.1038/ng.3498

Sveinbjornsson, G., Bulat Kardum, Lj. and Knežević, J. (2016) 'HLA class II sequence variants influence tuberculosis risk in populations of European ancestry', Nature genetics, 48(3), pp. 318-322. doi: 10.1038/ng.3498

Sveinbjornsson G, Bulat Kardum Lj, Knežević J. HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature genetics [Internet]. 2016 [cited 2024 May 13];48(3):318-322. doi: 10.1038/ng.3498

G. Sveinbjornsson, Lj. Bulat Kardum and J. Knežević, "HLA class II sequence variants influence tuberculosis risk in populations of European ancestry", Nature genetics, vol. 48, no. 3, pp. 318-322, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:906681. [Accessed: 13 May 2024]

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Metadata
Title (english)HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
AuthorGardar Sveinbjornsson
AuthorLjiljana Bulat Kardum
AuthorJelena Knežević
Author
...
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5 million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 million variants identified through whole-genome sequencing of 2, 636 Icelanders for association with tuberculosis (8, 162 cases and 277, 643 controls), pulmonary tuberculosis (PTB) and M. tuberculosis infection. We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): rs557011[T] (minor allele frequency (MAF) = 40.2%), associated with M. tuberculosis infection (odds ratio (OR) = 1.14, P = 3.1 × 10(-13)) and PTB (OR = 1.25, P = 5.8 × 10(-12)), and rs9271378[G] (MAF = 32.5%), associated with PTB (OR = 0.78, P = 2.5 × 10(-12))-both located between HLA-DQA1 and HLA-DRB1-and a missense variant encoding p.Ala210Thr in HLA-DQA1 (MAF = 19.1%, rs9272785), associated with M. tuberculosis infection (P = 9.3 × 10(-9), OR = 1.14). We replicated association of these variants with PTB in samples of European ancestry from Russia and Croatia (P < 5.9 × 10(-4)). These findings show that the HLA class II region contributes to genetic risk of tuberculosis, possibly through reduced presentation of protective M. tuberculosis antigens to T cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleNature genetics
Numberingvol. 48, no. 3, pp. 318-322
p-ISSN1061-4036
DOIhttps://doi.org/10.1038/ng.3498
URN:NBNurn:nbn:hr:184:906681
Publication2016
Document URLhttp://bib.irb.hr/818514
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-02-21 17:57:18