prikaz prve stranice dokumenta Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation
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Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation
Food and Chemical Toxicology, 98 (2016), Part B; 251-261. https://doi.org/10.1016/j.fct.2016.11.004
Potočnjak, Iva; Domitrović, Robert

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Potočnjak, I. i Domitrović, R. (2016). Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation. Food and Chemical Toxicology, 98. (Part B), 251-261. doi: 10.1016/j.fct.2016.11.004

Potočnjak, Iva i Robert Domitrović. "Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation." Food and Chemical Toxicology, vol. 98, br. Part B, 2016, str. 251-261. https://doi.org/10.1016/j.fct.2016.11.004

Potočnjak, Iva i Robert Domitrović. "Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation." Food and Chemical Toxicology 98, br. Part B (2016): 251-261. https://doi.org/10.1016/j.fct.2016.11.004

Potočnjak, I. i Domitrović, R. (2016) 'Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation', Food and Chemical Toxicology, 98(Part B), str. 251-261. doi: 10.1016/j.fct.2016.11.004

Potočnjak I, Domitrović R. Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation. Food and Chemical Toxicology [Internet]. 2016. [pristupljeno 26.12.2024.];98(Part B):251-261. doi: 10.1016/j.fct.2016.11.004

I. Potočnjak i R. Domitrović, "Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation", Food and Chemical Toxicology, vol. 98, br. Part B, str. 251-261, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:114385. [Citirano: 26.12.2024.]

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Naslov (engleski)Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation
AutorIva Potočnjak
AutorRobert Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
We investigated the mechanisms of renoprotective effects of carvacrol, a monoterpenoid compound, against cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 1, 3, and 10 mg carvacrol/kg body weight for two days, 48 h after intraperitoneal injection of CP (13 mg/kg). Four days after CP administration, renal oxidative stress was evidenced by increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), cytochrome P450 E1 (CYP2E1), and heme oxygenase-1 (HO-1). CP treatment increased the expression of phosphorylated nuclear factor-kappaB (p-NF-κB) p65 and tumor necrosis factor-alpha (TNF-α) in kidneys, suggesting inflammatory response. CP intoxication induced apoptosis and inhibition of the cell cycle in kidneys by increasing the expression of p53 and Bax and suppressing Bcl-2 and cyclin D1 expression. Concomitant increase in p21 and proliferating cell nuclear antigen (PCNA) expression suggested enhanced DNA repair process. CP administration also resulted in activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) with concomitant induction of phosphorylated Akt and suppression of phosphatase and tensin homolog (PTEN) expression. All these changes were dose-dependently restored by carvacrol. The results of the current study suggest that carvacrol could attenuate CP-induced acute renal injury by suppressing oxidative stress, apoptosis, and inflammation through modulation of the ERK and PI3K/Akt pathways.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFood and Chemical Toxicology
Brojčani podacivol. 98, br. Part B, str. 251-261
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2016.11.004
URN:NBNurn:nbn:hr:184:114385
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/827505
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-09 14:56:09