prikaz prve stranice dokumenta Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation
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Scientific paper - Original scientific paper
Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation
Food and Chemical Toxicology, 98 (2016), Part B; 251-261. https://doi.org/10.1016/j.fct.2016.11.004
Potočnjak, Iva; Domitrović, Robert

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Potočnjak, I. & Domitrović, R. (2016). Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation. Food and Chemical Toxicology, 98. (Part B), 251-261. doi: 10.1016/j.fct.2016.11.004

Potočnjak, Iva and Robert Domitrović. "Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation." Food and Chemical Toxicology, vol. 98, no. Part B, 2016, pp. 251-261. https://doi.org/10.1016/j.fct.2016.11.004

Potočnjak, Iva and Robert Domitrović. "Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation." Food and Chemical Toxicology 98, no. Part B (2016): 251-261. https://doi.org/10.1016/j.fct.2016.11.004

Potočnjak, I. and Domitrović, R. (2016) 'Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation', Food and Chemical Toxicology, 98(Part B), pp. 251-261. doi: 10.1016/j.fct.2016.11.004

Potočnjak I, Domitrović R. Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation. Food and Chemical Toxicology [Internet]. 2016 [cited 2024 November 13];98(Part B):251-261. doi: 10.1016/j.fct.2016.11.004

I. Potočnjak and R. Domitrović, "Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation", Food and Chemical Toxicology, vol. 98, no. Part B, pp. 251-261, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:114385. [Accessed: 13 November 2024]

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Metadata
Title (english)Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation
AuthorIva Potočnjak
AuthorRobert Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
We investigated the mechanisms of renoprotective effects of carvacrol, a monoterpenoid compound, against cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 1, 3, and 10 mg carvacrol/kg body weight for two days, 48 h after intraperitoneal injection of CP (13 mg/kg). Four days after CP administration, renal oxidative stress was evidenced by increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), cytochrome P450 E1 (CYP2E1), and heme oxygenase-1 (HO-1). CP treatment increased the expression of phosphorylated nuclear factor-kappaB (p-NF-κB) p65 and tumor necrosis factor-alpha (TNF-α) in kidneys, suggesting inflammatory response. CP intoxication induced apoptosis and inhibition of the cell cycle in kidneys by increasing the expression of p53 and Bax and suppressing Bcl-2 and cyclin D1 expression. Concomitant increase in p21 and proliferating cell nuclear antigen (PCNA) expression suggested enhanced DNA repair process. CP administration also resulted in activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) with concomitant induction of phosphorylated Akt and suppression of phosphatase and tensin homolog (PTEN) expression. All these changes were dose-dependently restored by carvacrol. The results of the current study suggest that carvacrol could attenuate CP-induced acute renal injury by suppressing oxidative stress, apoptosis, and inflammation through modulation of the ERK and PI3K/Akt pathways.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFood and Chemical Toxicology
Numberingvol. 98, no. Part B, pp. 251-261
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2016.11.004
URN:NBNurn:nbn:hr:184:114385
Publication2016
Document URLhttp://bib.irb.hr/827505
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-09 14:56:09