prikaz prve stranice dokumenta Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium
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Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium
Biology of Reproduction, 102 (2020), 5; 1111-1121. https://doi.org/10.1093/biolre/ioaa013
Šućurović, Sandra; Nikolić, Tamara; Brosens, Jan J; Mulac-Jeričević, Biserka

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Šućurović, S., Nikolić, T., Brosens, J. J. i Mulac Jeričević, B. (2020). Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium. Biology of Reproduction, 102. (5), 1111-1121. doi: 10.1093/biolre/ioaa013

Šućurović, Sandra, et al. "Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium." Biology of Reproduction, vol. 102, br. 5, 2020, str. 1111-1121. https://doi.org/10.1093/biolre/ioaa013

Šućurović, Sandra, Tamara Nikolić, Jan J Brosens i Biserka Mulac Jeričević. "Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium." Biology of Reproduction 102, br. 5 (2020): 1111-1121. https://doi.org/10.1093/biolre/ioaa013

Šućurović, S., et al. (2020) 'Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium', Biology of Reproduction, 102(5), str. 1111-1121. doi: 10.1093/biolre/ioaa013

Šućurović S, Nikolić T, Brosens JJ, Mulac Jeričević B. Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium. Biology of Reproduction [Internet]. 2020. [pristupljeno 26.12.2024.];102(5):1111-1121. doi: 10.1093/biolre/ioaa013

S. Šućurović, T. Nikolić, J. J. Brosens i B. Mulac Jeričević, "Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium", Biology of Reproduction, vol. 102, br. 5, str. 1111-1121, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:963053. [Citirano: 26.12.2024.]

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Naslov (engleski)Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium
Naslov (engleski)Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium†
AutorSandra Šućurović
AutorTamara Nikolić
AutorJan J Brosens
AutorBiserka Mulac-Jeričević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Implantation is restricted to a narrow window when the local endometrial microenvironment is supportive of the invading embryo. The ovarian steroid hormones estrogen (E) and progesterone (P) are principal regulators of uterine receptivity. Suppression of E-dependent proliferation of luminal epithelium (LE) by P is mandatory for embryo implantation. Here, we report that the balance of E receptor α (ERα) and P receptors (PR) activity controls HAND2 expression, a key transcription factor that determines the fate of the implanting embryo and thereby pregnancy outcome. As a model, we used wild-type mice as well as mice in which either both PR isoforms or the A-isoform was genetically ablated (PRKO and PRAKO, respectively). Detailed spatiotemporal analyses of PR, HAND2, and ERα expression at implantation site demonstrated co-expression of HAND2 and PR but not ERα. Furthermore, in hormonally treated ovariectomized WT, PRAKO and PRKO mice, E suppresses endometrial HAND2 expression. Adding P together with E partially rescues HAND2 expression in WT, but not PRAKO and PRKO animals. Therefore, infertility in PRAKO mice is at least in part associated with the loss of PR-A-regulated HAND2 expression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiology of Reproduction
Brojčani podacivol. 102, br. 5, str. 1111-1121
p-ISSN0006-3363
DOIhttps://doi.org/10.1093/biolre/ioaa013
URN:NBNurn:nbn:hr:184:963053
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1106884
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-07 14:45:06