prikaz prve stranice dokumenta Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium
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Scientific paper - Original scientific paper
Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium
Biology of Reproduction, 102 (2020), 5; 1111-1121. https://doi.org/10.1093/biolre/ioaa013
Šućurović, Sandra; Nikolić, Tamara; Brosens, Jan J; Mulac-Jeričević, Biserka

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Šućurović, S., Nikolić, T., Brosens, J. J. & Mulac Jeričević, B. (2020). Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium. Biology of Reproduction, 102. (5), 1111-1121. doi: 10.1093/biolre/ioaa013

Šućurović, Sandra, et al. "Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium." Biology of Reproduction, vol. 102, no. 5, 2020, pp. 1111-1121. https://doi.org/10.1093/biolre/ioaa013

Šućurović, Sandra, Tamara Nikolić, Jan J Brosens and Biserka Mulac Jeričević. "Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium." Biology of Reproduction 102, no. 5 (2020): 1111-1121. https://doi.org/10.1093/biolre/ioaa013

Šućurović, S., et al. (2020) 'Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium', Biology of Reproduction, 102(5), pp. 1111-1121. doi: 10.1093/biolre/ioaa013

Šućurović S, Nikolić T, Brosens JJ, Mulac Jeričević B. Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium. Biology of Reproduction [Internet]. 2020 [cited 2024 November 25];102(5):1111-1121. doi: 10.1093/biolre/ioaa013

S. Šućurović, T. Nikolić, J. J. Brosens and B. Mulac Jeričević, "Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium", Biology of Reproduction, vol. 102, no. 5, pp. 1111-1121, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:963053. [Accessed: 25 November 2024]

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Title (english)Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium
Title (english)Analysis of heart and neural crest derivatives- expressed protein 2 (HAND2)-progesterone interactions in peri-implantation endometrium†
AuthorSandra Šućurović
AuthorTamara Nikolić
AuthorJan J Brosens
AuthorBiserka Mulac-Jeričević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Implantation is restricted to a narrow window when the local endometrial microenvironment is supportive of the invading embryo. The ovarian steroid hormones estrogen (E) and progesterone (P) are principal regulators of uterine receptivity. Suppression of E-dependent proliferation of luminal epithelium (LE) by P is mandatory for embryo implantation. Here, we report that the balance of E receptor α (ERα) and P receptors (PR) activity controls HAND2 expression, a key transcription factor that determines the fate of the implanting embryo and thereby pregnancy outcome. As a model, we used wild-type mice as well as mice in which either both PR isoforms or the A-isoform was genetically ablated (PRKO and PRAKO, respectively). Detailed spatiotemporal analyses of PR, HAND2, and ERα expression at implantation site demonstrated co-expression of HAND2 and PR but not ERα. Furthermore, in hormonally treated ovariectomized WT, PRAKO and PRKO mice, E suppresses endometrial HAND2 expression. Adding P together with E partially rescues HAND2 expression in WT, but not PRAKO and PRKO animals. Therefore, infertility in PRAKO mice is at least in part associated with the loss of PR-A-regulated HAND2 expression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiology of Reproduction
Numberingvol. 102, no. 5, pp. 1111-1121
p-ISSN0006-3363
DOIhttps://doi.org/10.1093/biolre/ioaa013
URN:NBNurn:nbn:hr:184:963053
Publication2020
Document URLhttp://bib.irb.hr/1106884
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-07 14:45:06