prikaz prve stranice dokumenta A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion
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A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion
American Journal of Reproductive Immunology, 78 (2017), 6; 1-7. https://doi.org/10.1111/aji.12765
Barišić, Anita; Pereza, Nina; Hodžić, Alenka; Ostojić, Saša; Peterlin, Borut

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Barišić, A., Pereza, N., Hodžić, A., Ostojić, S. i Peterlin, B. (2017). A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion. American Journal of Reproductive Immunology, 78. (6), 1-7. doi: 10.1111/aji.12765

Barišić, Anita, et al. "A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion." American Journal of Reproductive Immunology, vol. 78, br. 6, 2017, str. 1-7. https://doi.org/10.1111/aji.12765

Barišić, Anita, Nina Pereza, Alenka Hodžić, Saša Ostojić i Borut Peterlin. "A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion." American Journal of Reproductive Immunology 78, br. 6 (2017): 1-7. https://doi.org/10.1111/aji.12765

Barišić, A., et al. (2017) 'A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion', American Journal of Reproductive Immunology, 78(6), str. 1-7. doi: 10.1111/aji.12765

Barišić A, Pereza N, Hodžić A, Ostojić S, Peterlin B. A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion. American Journal of Reproductive Immunology [Internet]. 2017. [pristupljeno 12.11.2024.];78(6):1-7. doi: 10.1111/aji.12765

A. Barišić, N. Pereza, A. Hodžić, S. Ostojić i B. Peterlin, "A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion", American Journal of Reproductive Immunology, vol. 78, br. 6, str. 1-7, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:303352. [Citirano: 12.11.2024.]

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Podaci o radu
Naslov (engleski)A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion
AutorAnita Barišić
AutorNina Pereza
AutorAlenka Hodžić
AutorSaša Ostojić
AutorBorut Peterlin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Sažetak (engleski)
Aberrant DNA methylation has been suggested as a potential cause of recurrent spontaneous abortion (RSA). Considering the growing evidence on the important roles of DNA methylation in gametogenesis and early pregnancy, we investigated the potential association of DNA methyltransferase gene polymorphisms (DNMT1 rs2228611, DNMT3A rs1550117, DNMT3B rs1569686) with RSA in Slovenian reproductive couples. A total of 146 couples with ≥3 consecutive spontaneous abortions and 149 control women and men with ≥2 normal pregnancies were included. Genotyping was performed using PCR- RFLP methods. We found a statistically significant higher frequency of the DNMT3B rs1569686 GG genotype (X2=7.37 ; P = .025) and G allele (X2 = 6.33 ; P = .012) in RSA women compared with controls. Moreover, the odds for RSA in women were increased under the recessive genetic model (GGvsTG+TT: OR=1.92 ; 95% CI=1.18-3.09 ; P = .008). DNMT3B rs1569686 gene polymorphism in women might be a genetic marker for the susceptibility to RSA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Reproductive Immunology
Brojčani podacivol. 78, br. 6, str. 1-7
p-ISSN1046-7408
e-ISSN1600-0897
DOIhttps://doi.org/10.1111/aji.12765
URN:NBNurn:nbn:hr:184:303352
Datum objave publikacije2017
URL dokumentahttp://bib.irb.hr/894955
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-03 11:48:47