prikaz prve stranice dokumenta A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion
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Scientific paper - Original scientific paper
A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion
American Journal of Reproductive Immunology, 78 (2017), 6; 1-7. https://doi.org/10.1111/aji.12765
Barišić, Anita; Pereza, Nina; Hodžić, Alenka; Ostojić, Saša; Peterlin, Borut

Cite this document

Barišić, A., Pereza, N., Hodžić, A., Ostojić, S. & Peterlin, B. (2017). A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion. American Journal of Reproductive Immunology, 78. (6), 1-7. doi: 10.1111/aji.12765

Barišić, Anita, et al. "A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion." American Journal of Reproductive Immunology, vol. 78, no. 6, 2017, pp. 1-7. https://doi.org/10.1111/aji.12765

Barišić, Anita, Nina Pereza, Alenka Hodžić, Saša Ostojić and Borut Peterlin. "A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion." American Journal of Reproductive Immunology 78, no. 6 (2017): 1-7. https://doi.org/10.1111/aji.12765

Barišić, A., et al. (2017) 'A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion', American Journal of Reproductive Immunology, 78(6), pp. 1-7. doi: 10.1111/aji.12765

Barišić A, Pereza N, Hodžić A, Ostojić S, Peterlin B. A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion. American Journal of Reproductive Immunology [Internet]. 2017 [cited 2024 November 18];78(6):1-7. doi: 10.1111/aji.12765

A. Barišić, N. Pereza, A. Hodžić, S. Ostojić and B. Peterlin, "A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion", American Journal of Reproductive Immunology, vol. 78, no. 6, pp. 1-7, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:303352. [Accessed: 18 November 2024]

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Metadata
Title (english)A single nucleotide polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion
AuthorAnita Barišić
AuthorNina Pereza
AuthorAlenka Hodžić
AuthorSaša Ostojić
AuthorBorut Peterlin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract (english)
Aberrant DNA methylation has been suggested as a potential cause of recurrent spontaneous abortion (RSA). Considering the growing evidence on the important roles of DNA methylation in gametogenesis and early pregnancy, we investigated the potential association of DNA methyltransferase gene polymorphisms (DNMT1 rs2228611, DNMT3A rs1550117, DNMT3B rs1569686) with RSA in Slovenian reproductive couples. A total of 146 couples with ≥3 consecutive spontaneous abortions and 149 control women and men with ≥2 normal pregnancies were included. Genotyping was performed using PCR- RFLP methods. We found a statistically significant higher frequency of the DNMT3B rs1569686 GG genotype (X2=7.37 ; P = .025) and G allele (X2 = 6.33 ; P = .012) in RSA women compared with controls. Moreover, the odds for RSA in women were increased under the recessive genetic model (GGvsTG+TT: OR=1.92 ; 95% CI=1.18-3.09 ; P = .008). DNMT3B rs1569686 gene polymorphism in women might be a genetic marker for the susceptibility to RSA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAmerican Journal of Reproductive Immunology
Numberingvol. 78, no. 6, pp. 1-7
p-ISSN1046-7408
e-ISSN1600-0897
DOIhttps://doi.org/10.1111/aji.12765
URN:NBNurn:nbn:hr:184:303352
Publication2017
Document URLhttp://bib.irb.hr/894955
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-03 11:48:47