prikaz prve stranice dokumenta Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector
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Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector
Cell Host & Microbe, 27 (2020), 4; 571-584.e7. https://doi.org/10.1016/j.chom.2020.03.003
Price, Christopher; Jones, Snake; Mihelčić, Mirna; Šantić, Marina; Abu Kwaik, Yousef

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Price, C., Jones, S., Mihelčić, M., Šantić, M. i Abu Kwaik, Y. (2020). Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector. Cell Host & Microbe, 27. (4), 571-584.e7. doi: 10.1016/j.chom.2020.03.003

Price, Christopher, et al. "Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector." Cell Host & Microbe, vol. 27, br. 4, 2020, str. 571-584.e7. https://doi.org/10.1016/j.chom.2020.03.003

Price, Christopher, Snake Jones, Mirna Mihelčić, Marina Šantić i Yousef Abu Kwaik. "Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector." Cell Host & Microbe 27, br. 4 (2020): 571-584.e7. https://doi.org/10.1016/j.chom.2020.03.003

Price, C., et al. (2020) 'Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector', Cell Host & Microbe, 27(4), str. 571-584.e7. doi: 10.1016/j.chom.2020.03.003

Price C, Jones S, Mihelčić M, Šantić M, Abu Kwaik Y. Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector. Cell Host & Microbe [Internet]. 04.2020. [pristupljeno 13.11.2024.];27(4):571-584.e7. doi: 10.1016/j.chom.2020.03.003

C. Price, S. Jones, M. Mihelčić, M. Šantić i Y. Abu Kwaik, "Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector", Cell Host & Microbe, vol. 27, br. 4, str. 571-584.e7, Travanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:329055. [Citirano: 13.11.2024.]

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Naslov (engleski)Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector
AutorChristopher Price
AutorSnake Jones
AutorMirna Mihelčić
AutorMarina Šantić
AutorYousef Abu Kwaik
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Legionella pneumophila has co-evolved with amoebae, their natural hosts. Upon transmission to humans, the bacteria proliferate within alveolar macrophages causing pneumonia. Here, we show L. pneumophila injects the effector LamA, an amylase, into the cytosol of human macrophage (hMDMs) and amoebae to rapidly degrade glycogen to generate cytosolic hyper-glucose. In response, hMDMs shift their metabolism to aerobic glycolysis, which directly triggers an M1-like pro-inflammatory differentiation and nutritional innate immunity through enhanced tryptophan degradation. This leads to a modest restriction of bacterial proliferation in hMDMs. In contrast, LamA-mediated glycogenolysis in amoebae deprives the natural host from the main building blocks for synthesis of the cellulose-rich cyst wall, leading to subversion of amoeba encystation. This is non-permissive for bacterial proliferation. Therefore, LamA of L. pneumophila is an amoebae host-adapted effector that subverts encystation of the amoebae natural host, and the paradoxical hMDMs' pro-inflammatory response is likely an evolutionary accident.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCell Host & Microbe
Brojčani podacivol. 27, br. 4, str. 571-584.e7
p-ISSN1931-3128
DOIhttps://doi.org/10.1016/j.chom.2020.03.003
URN:NBNurn:nbn:hr:184:329055
Datum objave publikacije2020-04
ProjektŠifra: uniri-biomed-18-128
Naziv (hrvatski): Francisella molekularni mehanizmi prilagodbe na stanice amebama
Naziv (engleski): Francisella-the molecular mechanisms of adaptation on amoeba cells
Voditelj: Marina Šantić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1931312820301670
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-01-28 08:03:26