prikaz prve stranice dokumenta Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector
  Download
PDF 3.93 MB
Scientific paper - Original scientific paper
Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector
Cell Host & Microbe, 27 (2020), 4; 571-584.e7. https://doi.org/10.1016/j.chom.2020.03.003
Price, Christopher; Jones, Snake; Mihelčić, Mirna; Šantić, Marina; Abu Kwaik, Yousef

Cite this document

Price, C., Jones, S., Mihelčić, M., Šantić, M. & Abu Kwaik, Y. (2020). Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector. Cell Host & Microbe, 27. (4), 571-584.e7. doi: 10.1016/j.chom.2020.03.003

Price, Christopher, et al. "Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector." Cell Host & Microbe, vol. 27, no. 4, 2020, pp. 571-584.e7. https://doi.org/10.1016/j.chom.2020.03.003

Price, Christopher, Snake Jones, Mirna Mihelčić, Marina Šantić and Yousef Abu Kwaik. "Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector." Cell Host & Microbe 27, no. 4 (2020): 571-584.e7. https://doi.org/10.1016/j.chom.2020.03.003

Price, C., et al. (2020) 'Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector', Cell Host & Microbe, 27(4), pp. 571-584.e7. doi: 10.1016/j.chom.2020.03.003

Price C, Jones S, Mihelčić M, Šantić M, Abu Kwaik Y. Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector. Cell Host & Microbe [Internet]. 2020 April [cited 2024 November 22];27(4):571-584.e7. doi: 10.1016/j.chom.2020.03.003

C. Price, S. Jones, M. Mihelčić, M. Šantić and Y. Abu Kwaik, "Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector", Cell Host & Microbe, vol. 27, no. 4, pp. 571-584.e7, April 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:329055. [Accessed: 22 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Paradoxical Pro-inflammatory Responses by Human Macrophages to an Amoebae Host-Adapted Legionella Effector
AuthorChristopher Price
AuthorSnake Jones
AuthorMirna Mihelčić
AuthorMarina Šantić
AuthorYousef Abu Kwaik
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Legionella pneumophila has co-evolved with amoebae, their natural hosts. Upon transmission to humans, the bacteria proliferate within alveolar macrophages causing pneumonia. Here, we show L. pneumophila injects the effector LamA, an amylase, into the cytosol of human macrophage (hMDMs) and amoebae to rapidly degrade glycogen to generate cytosolic hyper-glucose. In response, hMDMs shift their metabolism to aerobic glycolysis, which directly triggers an M1-like pro-inflammatory differentiation and nutritional innate immunity through enhanced tryptophan degradation. This leads to a modest restriction of bacterial proliferation in hMDMs. In contrast, LamA-mediated glycogenolysis in amoebae deprives the natural host from the main building blocks for synthesis of the cellulose-rich cyst wall, leading to subversion of amoeba encystation. This is non-permissive for bacterial proliferation. Therefore, LamA of L. pneumophila is an amoebae host-adapted effector that subverts encystation of the amoebae natural host, and the paradoxical hMDMs' pro-inflammatory response is likely an evolutionary accident.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Host & Microbe
Numberingvol. 27, no. 4, pp. 571-584.e7
p-ISSN1931-3128
DOIhttps://doi.org/10.1016/j.chom.2020.03.003
URN:NBNurn:nbn:hr:184:329055
Publication2020-04
ProjectNumber: uniri-biomed-18-128
Title (croatian): Francisella molekularni mehanizmi prilagodbe na stanice amebama
Title (english): Francisella-the molecular mechanisms of adaptation on amoeba cells
Leader: Marina Šantić
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1931312820301670
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-01-28 08:03:26