prikaz prve stranice dokumenta Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
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Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
Nature Communications, 11 (2020), 1; 6324. https://doi.org/10.1038/s41467-020-20031-4
Ouwendijk, Werner J. D.; Depledge, Daniel P.; Rajbhandari, Labchan; Lenac Roviš, Tihana; Jonjić, Stipan; Breuer, Judith; Venkatesan, Arun; Verjans, Georges M. G. M.; Sadaoka, Tomohiko

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Ouwendijk, W. J. D., Depledge, D. P., Rajbhandari, L., Lenac Roviš, T., Jonjić, S., Breuer, J. ... Sadaoka, T. (2020). Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency. Nature Communications, 11. (1). doi: 10.1038/s41467-020-20031-4

Ouwendijk, Werner J. D., et al. "Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency." Nature Communications, vol. 11, br. 1, 2020. https://doi.org/10.1038/s41467-020-20031-4

Ouwendijk, Werner J. D., Daniel P. Depledge, Labchan Rajbhandari, Tihana Lenac Roviš, Stipan Jonjić, Judith Breuer, Arun Venkatesan, Georges M. G. M. Verjans i Tomohiko Sadaoka. "Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency." Nature Communications 11, br. 1 (2020). https://doi.org/10.1038/s41467-020-20031-4

Ouwendijk, W. J. D., et al. (2020) 'Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency', Nature Communications, 11(1). doi: 10.1038/s41467-020-20031-4

Ouwendijk WJD, Depledge DP, Rajbhandari L, Lenac Roviš T, Jonjić S, Breuer J, i sur.. Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency. Nature Communications [Internet]. 10.12.2020. [pristupljeno 05.12.2024.];11(1). doi: 10.1038/s41467-020-20031-4

W. J. D. Ouwendijk, et al., "Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency", Nature Communications, vol. 11, br. 1, Prosinac 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:287530. [Citirano: 05.12.2024.]

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Naslov (engleski)Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency
AutorWerner J. D. Ouwendijk
AutorDaniel P. Depledge
AutorLabchan Rajbhandari
AutorTihana Lenac Roviš
AutorStipan Jonjić
AutorJudith Breuer
AutorArun Venkatesan
AutorGeorges M. G. M. Verjans
AutorTomohiko Sadaoka
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Abstract Varicella-zoster virus (VZV) establishes lifelong neuronal latency in most humans world-wide, reactivating in one-third to cause herpes zoster and occasionally chronic pain. How VZV establishes, maintains and reactivates from latency is largely unknown. VZV transcription during latency is restricted to the latency-associated transcript (VLT) and RNA 63 (encoding ORF63) in naturally VZV-infected human trigeminal ganglia (TG). While significantly more abundant, VLT levels positively correlated with RNA 63 suggesting co-regulated transcription during latency. Here, we identify VLT-ORF63 fusion transcripts and confirm VLT-ORF63, but not RNA 63, expression in human TG neurons. During in vitro latency, VLT is transcribed, whereas VLT-ORF63 expression is induced by reactivation stimuli. One isoform of VLT-ORF63, encoding a fusion protein combining VLT and ORF63 proteins, induces broad viral gene transcription. Collectively, our findings show that VZV expresses a unique set of VLT-ORF63 transcripts, potentially involved in the transition from latency to lytic VZV infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 11, br. 1, 6324
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-020-20031-4
URN:NBNurn:nbn:hr:184:287530
Datum objave publikacije2020-12-10
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttp://www.nature.com/articles/s41467-020-20031-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-01-11 18:27:40