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Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage
Medicine, 99 (2020), 20; e19966. https://doi.org/10.1097/MD.0000000000019966
Sošić, Matija; Antončić, Igor; Tarčuković, Janja; Dunatov, Siniša; Šustić, Alan; Ćurko-Cofek, Božena; Sotošek, Vlatka

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Sošić, M., Antončić, I., Tarčuković, J., Dunatov, S., Šustić, A., Ćurko Cofek, B. i Sotošek, V. (2020). Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage. Medicine, 99. (20). doi: 10.1097/MD.0000000000019966

Sošić, Matija, et al. "Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage." Medicine, vol. 99, br. 20, 2020. https://doi.org/10.1097/MD.0000000000019966

Sošić, Matija, Igor Antončić, Janja Tarčuković, Siniša Dunatov, Alan Šustić, Božena Ćurko Cofek i Vlatka Sotošek. "Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage." Medicine 99, br. 20 (2020). https://doi.org/10.1097/MD.0000000000019966

Sošić, M., et al. (2020) 'Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage', Medicine, 99(20). doi: 10.1097/MD.0000000000019966

Sošić M, Antončić I, Tarčuković J, Dunatov S, Šustić A, Ćurko Cofek B, i sur.. Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage. Medicine [Internet]. 15.05.2020. [pristupljeno 11.11.2024.];99(20). doi: 10.1097/MD.0000000000019966

M. Sošić, et al., "Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage", Medicine, vol. 99, br. 20, Svibanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:615824. [Citirano: 11.11.2024.]

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Naslov (engleski)Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage
AutorMatija Sošić
AutorIgor Antončić
AutorJanja Tarčuković
AutorSiniša Dunatov
AutorAlan Šustić
AutorBožena Ćurko-Cofek
AutorVlatka Sotošek
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za neurologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
It is increasingly recognized that modulation of brain inflammation may uncover new potential therapeutic strategies for stroke. Recent studies have shifted focus from immunological implications in ischemic stroke to a more devastating form; the hemorrhagic stroke. The aim of this study was to investigate the neuroinflammatory response in cerebrospinal fluid in patients with primary intracerebral hemorrhage (ICH) associated with intraventricular hemorrhage (IVH) in the presence of low-dose recombinant tissue plasminogen activator (rt-PA). This retrospective study included 88 adults with primary ICH associated with IVH. Patients were divided into 2 groups: rt-PA group and non-rt-PA group, which received normal standard of care for this diagnosis. The rt-PA group was treated via catheter-based clot lysis using low-dose rt-PA injected through the external ventricular drain (EVD) system, and the non-rt-PA group was treated with saline applied to EVD system in equivalent volume. Cerebrospinal fluid samples from rt-PA were obtained from the EVD system at 4 time points: once before the drug administration, and then on day 1, 3, and 7. No attempt at randomization was made. The decision to inject rt-PA was based on the preference of the primary attending neurologist and the ability to obtain consent. Temporal interleukin-1 beta and transforming growth factor beta concentration changes were analyzed and compared between the 2 groups. The concentration of interleukin-1 beta was significantly lower in the rt-PA group than in the non-rt-PA group on day 7. In addition, the concentration of transforming growth factor beta was significantly higher in the rt-PA group than in the non-rt-PA group on day 1. There was a significant difference in interleukin-1 beta concentration between days 0 and 1 in comparison to day 3 in the rt-PA group, and between day 0 in comparison to day 3 and 7 in the non-rt-PA group. We also observed a significant difference in transforming growth factor beta concentration between days 0 and 1 and between days 3 and 7. The different pattern of pro- and anti-inflammatory cytokines in patients with ICH associated with IVH suggest distinct characteristics of secondary brain injury depending on the treatment modality.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedicine
Brojčani podacivol. 99, br. 20, e19966
p-ISSN0025-7974
e-ISSN1536-5964
DOIhttps://doi.org/10.1097/MD.0000000000019966
URN:NBNurn:nbn:hr:184:615824
Datum objave publikacije2020-05-15
URL dokumentahttps://journals.lww.com/10.1097/MD.0000000000019966
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2020-11-17 19:36:40