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Scientific paper - Original scientific paper
Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage
Medicine, 99 (2020), 20; e19966. https://doi.org/10.1097/MD.0000000000019966
Sošić, Matija; Antončić, Igor; Tarčuković, Janja; Dunatov, Siniša; Šustić, Alan; Ćurko-Cofek, Božena; Sotošek, Vlatka

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Sošić, M., Antončić, I., Tarčuković, J., Dunatov, S., Šustić, A., Ćurko Cofek, B. & Sotošek, V. (2020). Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage. Medicine, 99. (20). doi: 10.1097/MD.0000000000019966

Sošić, Matija, et al. "Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage." Medicine, vol. 99, no. 20, 2020. https://doi.org/10.1097/MD.0000000000019966

Sošić, Matija, Igor Antončić, Janja Tarčuković, Siniša Dunatov, Alan Šustić, Božena Ćurko Cofek and Vlatka Sotošek. "Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage." Medicine 99, no. 20 (2020). https://doi.org/10.1097/MD.0000000000019966

Sošić, M., et al. (2020) 'Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage', Medicine, 99(20). doi: 10.1097/MD.0000000000019966

Sošić M, Antončić I, Tarčuković J, Dunatov S, Šustić A, Ćurko Cofek B, and sur.. Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage. Medicine [Internet]. 2020 May 15 [cited 2024 April 27];99(20). doi: 10.1097/MD.0000000000019966

M. Sošić, et al., "Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage", Medicine, vol. 99, no. 20, May 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:615824. [Accessed: 27 April 2024]

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Title (english)Effect of intraventricularly administered low-dose recombinant tissue plasminogen activator on interleukin 1-beta and transforming growth factor beta concentrations in cerebrospinal fluid of patients with primary intracerebral hemorrhage associated with intraventricular hemorrhage
AuthorMatija Sošić
AuthorIgor Antončić
AuthorJanja Tarčuković
AuthorSiniša Dunatov
AuthorAlan Šustić
AuthorBožena Ćurko-Cofek
AuthorVlatka Sotošek
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
It is increasingly recognized that modulation of brain inflammation may uncover new potential therapeutic strategies for stroke. Recent studies have shifted focus from immunological implications in ischemic stroke to a more devastating form; the hemorrhagic stroke. The aim of this study was to investigate the neuroinflammatory response in cerebrospinal fluid in patients with primary intracerebral hemorrhage (ICH) associated with intraventricular hemorrhage (IVH) in the presence of low-dose recombinant tissue plasminogen activator (rt-PA). This retrospective study included 88 adults with primary ICH associated with IVH. Patients were divided into 2 groups: rt-PA group and non-rt-PA group, which received normal standard of care for this diagnosis. The rt-PA group was treated via catheter-based clot lysis using low-dose rt-PA injected through the external ventricular drain (EVD) system, and the non-rt-PA group was treated with saline applied to EVD system in equivalent volume. Cerebrospinal fluid samples from rt-PA were obtained from the EVD system at 4 time points: once before the drug administration, and then on day 1, 3, and 7. No attempt at randomization was made. The decision to inject rt-PA was based on the preference of the primary attending neurologist and the ability to obtain consent. Temporal interleukin-1 beta and transforming growth factor beta concentration changes were analyzed and compared between the 2 groups. The concentration of interleukin-1 beta was significantly lower in the rt-PA group than in the non-rt-PA group on day 7. In addition, the concentration of transforming growth factor beta was significantly higher in the rt-PA group than in the non-rt-PA group on day 1. There was a significant difference in interleukin-1 beta concentration between days 0 and 1 in comparison to day 3 in the rt-PA group, and between day 0 in comparison to day 3 and 7 in the non-rt-PA group. We also observed a significant difference in transforming growth factor beta concentration between days 0 and 1 and between days 3 and 7. The different pattern of pro- and anti-inflammatory cytokines in patients with ICH associated with IVH suggest distinct characteristics of secondary brain injury depending on the treatment modality.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicine
Numberingvol. 99, no. 20, e19966
p-ISSN0025-7974
e-ISSN1536-5964
DOIhttps://doi.org/10.1097/MD.0000000000019966
URN:NBNurn:nbn:hr:184:615824
Publication2020-05-15
Document URLhttps://journals.lww.com/10.1097/MD.0000000000019966
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2020-11-17 19:36:40