prikaz prve stranice dokumenta BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
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BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
American Journal of Physiology - Gastrointestinal and Liver Physiology, 302 (2012), 10; G1151-G1162. https://doi.org/10.1152/ajpgi.00244.2011
Marić, Ivana; Kučić, Natalia; Turk, Tamara; Smoljan, Ivana; Grahovac, Blaženka; Zoričić Cvek, Sanja; Ćelić, Tanja; Bobinac, Dragica; Vukičević, Slobodan

Citirajte ovaj rad

Marić, I., Kučić, N., Turk, T., Smoljan, I., Grahovac, B., Zoričić Cvek, S. ... Vukičević, S. (2012). BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy. American Journal of Physiology - Gastrointestinal and Liver Physiology, 302. (10), G1151-G1162. doi: 10.1152/ajpgi.00244.2011

Marić, Ivana, et al. "BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy." American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 302, br. 10, 2012, str. G1151-G1162. https://doi.org/10.1152/ajpgi.00244.2011

Marić, Ivana, Natalia Kučić, Tamara Turk, Ivana Smoljan, Blaženka Grahovac, Sanja Zoričić Cvek, Tanja Ćelić, Dragica Bobinac i Slobodan Vukičević. "BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy." American Journal of Physiology - Gastrointestinal and Liver Physiology 302, br. 10 (2012): G1151-G1162. https://doi.org/10.1152/ajpgi.00244.2011

Marić, I., et al. (2012) 'BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy', American Journal of Physiology - Gastrointestinal and Liver Physiology, 302(10), str. G1151-G1162. doi: 10.1152/ajpgi.00244.2011

Marić I, Kučić N, Turk T, Smoljan I, Grahovac B, Zoričić Cvek S, i sur.. BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy. American Journal of Physiology - Gastrointestinal and Liver Physiology [Internet]. 2012. [pristupljeno 12.11.2024.];302(10):G1151-G1162. doi: 10.1152/ajpgi.00244.2011

I. Marić, et al., "BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy", American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 302, br. 10, str. G1151-G1162, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:920660. [Citirano: 12.11.2024.]

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Naslov (engleski)BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
AutorIvana Marić
AutorNatalia Kučić
MBZ: 239812
AutorTamara Turk
AutorIvana Smoljan
AutorBlaženka Grahovac
AutorSanja Zoričić Cvek
AutorTanja Ćelić
AutorDragica Bobinac
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Beyond stimulating bone formation, the bone morphogenetic proteins (BMPs) are important in development, inflammation and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory and anti- proliferative effect on experimental inflammatory bowel disease (IBD) in rat. To further investigate the BMP signaling pathway we monitored the effect of BMP7 therapy on the BMP signaling components in rat colon during different stages of experimentally induced colitis by 2, 4, 6- trinitrobenzene sulfonic acid (TNBS). The results showed increased of BMP2 and -7 expression in the chronic phase of colitis. BMP7 treatment slightly enhanced BMP4, -6 and -7, and suppressed the BMP2 expression. CTGF and noggin expression was elevated in TNBS colitis, and slightly decreased upon BMP7 therapy. BMP receptor I expression was unchanged, while BMP receptor II was increased at day 14 and 30 of TNBS inflammation, and decreased following BMP7 therapy. BMP7 increased Smad1, Smad3 and Smad4. Inhibitory Smads were increased in colitis, but not in rats treated with BMP7. We conclude that BMP signaling is preserved in colon during TNBS-induced colonic inflammation and could be modulated with BMP7, suggesting that IBD is a reversible process with self-recovery features.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Brojčani podacivol. 302, br. 10, str. G1151-G1162
p-ISSN0193-1857
e-ISSN1522-1547
DOIhttps://doi.org/10.1152/ajpgi.00244.2011
URN:NBNurn:nbn:hr:184:920660
Datum objave publikacije2012
ProjektŠifra: 062-0000000-3540
Naziv (hrvatski): Endocitoza MHC molekula I razreda u stanicama inficiranim citomegalovirusom
Voditelj: Natalia Kučić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0000000-3550
Naziv (hrvatski): Molekularni mehanizmi infekcije virusom hepatitisa C
Voditelj: Blaženka Grahovac
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0000000-3559
Naziv (hrvatski): Uloga koštanih morfogenih proteina i inhibitora u nastanku osteofita čovjeka
Voditelj: Sanja Zoričić Cvek
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0620226-0207
Naziv (hrvatski): Promjene koštanog metabolizma u bolestima bubrega i jetre
Voditelj: Dragica Bobinac
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0620226-0208
Naziv (hrvatski): Kost kao ciljni organ u šećernoj bolesti i upalnim bolestima crijeva
Voditelj: Željka Crnčević Orlić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0620226-0209
Naziv (hrvatski): Koštani morfogenetski protein-7 i kost u modelu upalne bolesti crijeva
Voditelj: Ivana Marić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 108-1080327-0320
Naziv (hrvatski): Uloga TSH u modelu osteoporoze i u bolesnica sa smanjenom koštanom masom
Voditelj: Slobodan Vukičević
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/552856
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2020-04-23 17:53:46