prikaz prve stranice dokumenta BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
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Scientific paper - Original scientific paper
BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
American Journal of Physiology - Gastrointestinal and Liver Physiology, 302 (2012), 10; G1151-G1162. https://doi.org/10.1152/ajpgi.00244.2011
Marić, Ivana; Kučić, Natalia; Turk, Tamara; Smoljan, Ivana; Grahovac, Blaženka; Zoričić Cvek, Sanja; Ćelić, Tanja; Bobinac, Dragica; Vukičević, Slobodan

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Marić, I., Kučić, N., Turk, T., Smoljan, I., Grahovac, B., Zoričić Cvek, S. ... Vukičević, S. (2012). BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy. American Journal of Physiology - Gastrointestinal and Liver Physiology, 302. (10), G1151-G1162. doi: 10.1152/ajpgi.00244.2011

Marić, Ivana, et al. "BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy." American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 302, no. 10, 2012, pp. G1151-G1162. https://doi.org/10.1152/ajpgi.00244.2011

Marić, Ivana, Natalia Kučić, Tamara Turk, Ivana Smoljan, Blaženka Grahovac, Sanja Zoričić Cvek, Tanja Ćelić, Dragica Bobinac and Slobodan Vukičević. "BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy." American Journal of Physiology - Gastrointestinal and Liver Physiology 302, no. 10 (2012): G1151-G1162. https://doi.org/10.1152/ajpgi.00244.2011

Marić, I., et al. (2012) 'BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy', American Journal of Physiology - Gastrointestinal and Liver Physiology, 302(10), pp. G1151-G1162. doi: 10.1152/ajpgi.00244.2011

Marić I, Kučić N, Turk T, Smoljan I, Grahovac B, Zoričić Cvek S, and sur.. BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy. American Journal of Physiology - Gastrointestinal and Liver Physiology [Internet]. 2012 [cited 2024 April 25];302(10):G1151-G1162. doi: 10.1152/ajpgi.00244.2011

I. Marić, et al., "BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy", American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 302, no. 10, pp. G1151-G1162, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:920660. [Accessed: 25 April 2024]

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Metadata
Title (english)BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy
AuthorIvana Marić
AuthorNatalia Kučić
MBZ: 239812
AuthorTamara Turk
AuthorIvana Smoljan
AuthorBlaženka Grahovac
AuthorSanja Zoričić Cvek
AuthorTanja Ćelić
AuthorDragica Bobinac
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Beyond stimulating bone formation, the bone morphogenetic proteins (BMPs) are important in development, inflammation and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory and anti- proliferative effect on experimental inflammatory bowel disease (IBD) in rat. To further investigate the BMP signaling pathway we monitored the effect of BMP7 therapy on the BMP signaling components in rat colon during different stages of experimentally induced colitis by 2, 4, 6- trinitrobenzene sulfonic acid (TNBS). The results showed increased of BMP2 and -7 expression in the chronic phase of colitis. BMP7 treatment slightly enhanced BMP4, -6 and -7, and suppressed the BMP2 expression. CTGF and noggin expression was elevated in TNBS colitis, and slightly decreased upon BMP7 therapy. BMP receptor I expression was unchanged, while BMP receptor II was increased at day 14 and 30 of TNBS inflammation, and decreased following BMP7 therapy. BMP7 increased Smad1, Smad3 and Smad4. Inhibitory Smads were increased in colitis, but not in rats treated with BMP7. We conclude that BMP signaling is preserved in colon during TNBS-induced colonic inflammation and could be modulated with BMP7, suggesting that IBD is a reversible process with self-recovery features.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Numberingvol. 302, no. 10, pp. G1151-G1162
p-ISSN0193-1857
e-ISSN1522-1547
DOIhttps://doi.org/10.1152/ajpgi.00244.2011
URN:NBNurn:nbn:hr:184:920660
Publication2012
ProjectNumber: 062-0000000-3540
Title (croatian): Endocitoza MHC molekula I razreda u stanicama inficiranim citomegalovirusom
Leader: Natalia Kučić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0000000-3550
Title (croatian): Molekularni mehanizmi infekcije virusom hepatitisa C
Leader: Blaženka Grahovac
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0000000-3559
Title (croatian): Uloga koštanih morfogenih proteina i inhibitora u nastanku osteofita čovjeka
Leader: Sanja Zoričić Cvek
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0620226-0207
Title (croatian): Promjene koštanog metabolizma u bolestima bubrega i jetre
Leader: Dragica Bobinac
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0620226-0208
Title (croatian): Kost kao ciljni organ u šećernoj bolesti i upalnim bolestima crijeva
Leader: Željka Crnčević Orlić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0620226-0209
Title (croatian): Koštani morfogenetski protein-7 i kost u modelu upalne bolesti crijeva
Leader: Ivana Marić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 108-1080327-0320
Title (croatian): Uloga TSH u modelu osteoporoze i u bolesnica sa smanjenom koštanom masom
Leader: Slobodan Vukičević
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/552856
Type of resourceText
Access conditionsInstitutional access
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Created on2020-04-23 17:53:46