prikaz prve stranice dokumenta Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis
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Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis
Clinical & developmental immunology, 2013 (2013); 750406. https://doi.org/10.1155/2013/750406
Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka

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Grubić Kezele, T., Blagojević Zagorac, G., Jakovac, H., Domitrović, R., Milin, Č. i Radošević Stašić, B. (2013). Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis. Clinical & developmental immunology, 2013.. doi: 10.1155/2013/750406

Grubić Kezele, Tanja, et al. "Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis." Clinical & developmental immunology, vol. 2013, 2013. https://doi.org/10.1155/2013/750406

Grubić Kezele, Tanja, Gordana Blagojević Zagorac, Hrvoje Jakovac, Robert Domitrović, Čedomila Milin i Biserka Radošević Stašić. "Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis." Clinical & developmental immunology 2013 (2013). https://doi.org/10.1155/2013/750406

Grubić Kezele, T., et al. (2013) 'Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis', Clinical & developmental immunology, 2013. doi: 10.1155/2013/750406

Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrović R, Milin Č, Radošević Stašić B. Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis. Clinical & developmental immunology [Internet]. 2013. [pristupljeno 16.04.2024.];2013. doi: 10.1155/2013/750406

T. Grubić Kezele, G. Blagojević Zagorac, H. Jakovac, R. Domitrović, Č. Milin i B. Radošević Stašić, "Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis", Clinical & developmental immunology, vol. 2013, 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:677271. [Citirano: 16.04.2024.]

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Naslov (engleski)Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis
AutorTanja Grubić Kezele
AutorGordana Blagojević Zagorac
AutorHrvoje Jakovac
AutorRobert Domitrović
AutorČedomila Milin
AutorBiserka Radošević-Stašić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
In a search of peripheral factors that could be responsible for the discrepancy in susceptibility to EAE in Albino Oxford (AO) and Dark Agouti (DA) rats, we estimated the expression of metallothioneins I/II (MT), heat shock protein-gp96, interleukin (IL)-6 and transforming growth factor (TGF)-beta in the livers of these animals. Rats were immunized with bovine brain homogenate (BBH) emulsified in complete Freund adjuvant (CFA) or only with CFA. Western blot and immunohistochemical analyses were done on day 12 after the immunization, as well as in intact rats. The data have shown that during the first attack of EAE only the EAE prone-DA rats markedly upregulated the hepatic MTs, gp96, IL-6 and TGF- beta. In contrast, AO rats had a significantly higher expression of MT I/II, IL-6 and TGF-beta in intact liver (p<0, 001), suggesting that the greater constitutive expression of these proteins contributed to the resistance of EAE. Besides, since previously we found that AO rats reacted on immunization by an early upregulation of TGF-beta on several hepatic structures (vascular endothelium, Kupffer cells and hepatocytes), the data suggest that the specific hepatic microenvironment might contribute also to the faster recovery of these rats from EAE
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical & developmental immunology
Brojčani podacivol. 2013, 750406
p-ISSN1740-2522
DOIhttps://doi.org/10.1155/2013/750406
URN:NBNurn:nbn:hr:184:677271
Datum objave publikacije2013
ProjektŠifra: 062-0621341-0061
Naziv (hrvatski): Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva.
Voditelj: Čedomila Milin
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0621341-1337
Naziv (hrvatski): Morfogenetska svojstva stresnih proteina gp96 i metalotioneina
Voditelj: Biserka Radošević-Stašić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/652368
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-04-08 09:27:10