prikaz prve stranice dokumenta Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis
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Scientific paper - Original scientific paper
Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis
Clinical & developmental immunology, 2013 (2013); 750406. https://doi.org/10.1155/2013/750406
Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Milin, Čedomila; Radošević-Stašić, Biserka

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Grubić Kezele, T., Blagojević Zagorac, G., Jakovac, H., Domitrović, R., Milin, Č. & Radošević Stašić, B. (2013). Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis. Clinical & developmental immunology, 2013.. doi: 10.1155/2013/750406

Grubić Kezele, Tanja, et al. "Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis." Clinical & developmental immunology, vol. 2013, 2013. https://doi.org/10.1155/2013/750406

Grubić Kezele, Tanja, Gordana Blagojević Zagorac, Hrvoje Jakovac, Robert Domitrović, Čedomila Milin and Biserka Radošević Stašić. "Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis." Clinical & developmental immunology 2013 (2013). https://doi.org/10.1155/2013/750406

Grubić Kezele, T., et al. (2013) 'Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis', Clinical & developmental immunology, 2013. doi: 10.1155/2013/750406

Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrović R, Milin Č, Radošević Stašić B. Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis. Clinical & developmental immunology [Internet]. 2013 [cited 2024 December 23];2013. doi: 10.1155/2013/750406

T. Grubić Kezele, G. Blagojević Zagorac, H. Jakovac, R. Domitrović, Č. Milin and B. Radošević Stašić, "Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis", Clinical & developmental immunology, vol. 2013, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:677271. [Accessed: 23 December 2024]

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Title (english)Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF-beta in rat strains with different susceptibility to experimental autoimmune encephalomyelitis
AuthorTanja Grubić Kezele
AuthorGordana Blagojević Zagorac
AuthorHrvoje Jakovac
AuthorRobert Domitrović
AuthorČedomila Milin
AuthorBiserka Radošević-Stašić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
In a search of peripheral factors that could be responsible for the discrepancy in susceptibility to EAE in Albino Oxford (AO) and Dark Agouti (DA) rats, we estimated the expression of metallothioneins I/II (MT), heat shock protein-gp96, interleukin (IL)-6 and transforming growth factor (TGF)-beta in the livers of these animals. Rats were immunized with bovine brain homogenate (BBH) emulsified in complete Freund adjuvant (CFA) or only with CFA. Western blot and immunohistochemical analyses were done on day 12 after the immunization, as well as in intact rats. The data have shown that during the first attack of EAE only the EAE prone-DA rats markedly upregulated the hepatic MTs, gp96, IL-6 and TGF- beta. In contrast, AO rats had a significantly higher expression of MT I/II, IL-6 and TGF-beta in intact liver (p<0, 001), suggesting that the greater constitutive expression of these proteins contributed to the resistance of EAE. Besides, since previously we found that AO rats reacted on immunization by an early upregulation of TGF-beta on several hepatic structures (vascular endothelium, Kupffer cells and hepatocytes), the data suggest that the specific hepatic microenvironment might contribute also to the faster recovery of these rats from EAE
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical & developmental immunology
Numberingvol. 2013, 750406
p-ISSN1740-2522
DOIhttps://doi.org/10.1155/2013/750406
URN:NBNurn:nbn:hr:184:677271
Publication2013
ProjectNumber: 062-0621341-0061
Title (croatian): Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva.
Leader: Čedomila Milin
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0621341-1337
Title (croatian): Morfogenetska svojstva stresnih proteina gp96 i metalotioneina
Leader: Biserka Radošević-Stašić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/652368
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-04-08 09:27:10