prikaz prve stranice dokumenta Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis
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Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis
Acta Dermato-Venereologica, 99 (2019), 12; 1136-1142. https://doi.org/10.2340/00015555-3298
Vičić, Marijana; Kaštelan, Marija; Sotošek Tokmadžić, Vlatka; Prpić Massari, Larisa

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Vičić, M., Kaštelan, M., Sotošek Tokmadžić, V. i Prpić Massari, L. (2019). Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis. Acta Dermato-Venereologica, 99. (12), 1136-1142. doi: 10.2340/00015555-3298

Vičić, Marijana, et al. "Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis." Acta Dermato-Venereologica, vol. 99, br. 12, 2019, str. 1136-1142. https://doi.org/10.2340/00015555-3298

Vičić, Marijana, Marija Kaštelan, Vlatka Sotošek Tokmadžić i Larisa Prpić Massari. "Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis." Acta Dermato-Venereologica 99, br. 12 (2019): 1136-1142. https://doi.org/10.2340/00015555-3298

Vičić, M., et al. (2019) 'Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis', Acta Dermato-Venereologica, 99(12), str. 1136-1142. doi: 10.2340/00015555-3298

Vičić M, Kaštelan M, Sotošek Tokmadžić V, Prpić Massari L. Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis. Acta Dermato-Venereologica [Internet]. 2019. [pristupljeno 02.12.2024.];99(12):1136-1142. doi: 10.2340/00015555-3298

M. Vičić, M. Kaštelan, V. Sotošek Tokmadžić i L. Prpić Massari, "Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis", Acta Dermato-Venereologica, vol. 99, br. 12, str. 1136-1142, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:472066. [Citirano: 02.12.2024.]

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Podaci o radu
Naslov (engleski)Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis
AutorMarijana Vičić
AutorMarija Kaštelan
AutorVlatka Sotošek Tokmadžić
AutorLarisa Prpić Massari
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Psoriasis is considered to be a cytokine-driven immune-mediated disease, although the cell cytotoxicity mechanisms involved remain unrecognized. Herein, we analyzed granulysin expression in different lymphocyte subsets of peripheral blood of 40 psoriatic patients (20 with severe and 20 with mild psoriasis) and seven sample of psoriatic skin. The simultaneous detection of intracellular granulysin and cell surface antigens was performed using flow cytometry in peripheral blood and immunohistochemistry in skin lesions. The frequency of granulysin+ cells, mean fluorescence intensity for granulysin, and the frequency of CD8+ T lymphocytes, NK cells, and NKT cells expressing granulysin molecules in peripheral blood were significantly higher in patients with severe psoriasis compared to mild disease and healthy individuals. These were also correlated with disease severity. Furthermore, granulysin+ cells, CD8+granulysin+ T lymphocytes, and CD56+granulysin+ NK cells were present in a higher frequency in the epidermal basal cell layer and in the dermal infiltrate of lesional skin as compared to non-lesional and healthy skin. In conclusion, granulysin+ cytotoxic cells are upregulated in blood and lesions of patients with psoriasis suggesting the involvement of granulysin mediated cytotoxicity in psoriasis pathogenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Dermato-Venereologica
Brojčani podacivol. 99, br. 12, str. 1136-1142
p-ISSN0001-5555
e-ISSN1651-2057
DOIhttps://doi.org/10.2340/00015555-3298
URN:NBNurn:nbn:hr:184:472066
Datum objave publikacije2019
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2020-03-28 15:40:37