prikaz prve stranice dokumenta Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis
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Scientific paper - Original scientific paper
Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis
Acta Dermato-Venereologica, 99 (2019), 12; 1136-1142. https://doi.org/10.2340/00015555-3298
Vičić, Marijana; Kaštelan, Marija; Sotošek Tokmadžić, Vlatka; Prpić Massari, Larisa

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Vičić, M., Kaštelan, M., Sotošek Tokmadžić, V. & Prpić Massari, L. (2019). Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis. Acta Dermato-Venereologica, 99. (12), 1136-1142. doi: 10.2340/00015555-3298

Vičić, Marijana, et al. "Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis." Acta Dermato-Venereologica, vol. 99, no. 12, 2019, pp. 1136-1142. https://doi.org/10.2340/00015555-3298

Vičić, Marijana, Marija Kaštelan, Vlatka Sotošek Tokmadžić and Larisa Prpić Massari. "Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis." Acta Dermato-Venereologica 99, no. 12 (2019): 1136-1142. https://doi.org/10.2340/00015555-3298

Vičić, M., et al. (2019) 'Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis', Acta Dermato-Venereologica, 99(12), pp. 1136-1142. doi: 10.2340/00015555-3298

Vičić M, Kaštelan M, Sotošek Tokmadžić V, Prpić Massari L. Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis. Acta Dermato-Venereologica [Internet]. 2019 [cited 2024 April 21];99(12):1136-1142. doi: 10.2340/00015555-3298

M. Vičić, M. Kaštelan, V. Sotošek Tokmadžić and L. Prpić Massari, "Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis", Acta Dermato-Venereologica, vol. 99, no. 12, pp. 1136-1142, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:472066. [Accessed: 21 April 2024]

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Metadata
Title (english)Systemic and Local Increase of Granulysin Expression in Cytotoxic Lymphocytes in Severe Psoriasis
AuthorMarijana Vičić
AuthorMarija Kaštelan
AuthorVlatka Sotošek Tokmadžić
AuthorLarisa Prpić Massari
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Psoriasis is considered to be a cytokine-driven immune-mediated disease, although the cell cytotoxicity mechanisms involved remain unrecognized. Herein, we analyzed granulysin expression in different lymphocyte subsets of peripheral blood of 40 psoriatic patients (20 with severe and 20 with mild psoriasis) and seven sample of psoriatic skin. The simultaneous detection of intracellular granulysin and cell surface antigens was performed using flow cytometry in peripheral blood and immunohistochemistry in skin lesions. The frequency of granulysin+ cells, mean fluorescence intensity for granulysin, and the frequency of CD8+ T lymphocytes, NK cells, and NKT cells expressing granulysin molecules in peripheral blood were significantly higher in patients with severe psoriasis compared to mild disease and healthy individuals. These were also correlated with disease severity. Furthermore, granulysin+ cells, CD8+granulysin+ T lymphocytes, and CD56+granulysin+ NK cells were present in a higher frequency in the epidermal basal cell layer and in the dermal infiltrate of lesional skin as compared to non-lesional and healthy skin. In conclusion, granulysin+ cytotoxic cells are upregulated in blood and lesions of patients with psoriasis suggesting the involvement of granulysin mediated cytotoxicity in psoriasis pathogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Dermato-Venereologica
Numberingvol. 99, no. 12, pp. 1136-1142
p-ISSN0001-5555
e-ISSN1651-2057
DOIhttps://doi.org/10.2340/00015555-3298
URN:NBNurn:nbn:hr:184:472066
Publication2019
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2020-03-28 15:40:37