prikaz prve stranice dokumenta DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status
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DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status
Croatian medical journal, 61 (2020), 1; 8-17. urn:nbn:hr:184:150598
Barišić, Anita; Kolak, Maja; Peterlin, Ana; Tul, Nataša; Gašparović Krpina, Milena; Ostojić, Saša; Peterlin, Borut; Pereza, Nina

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Barišić, A., Kolak, M., Peterlin, A., Tul, N., Gašparović Krpina, M., Ostojić, S. ... Pereza, N. (2020). DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status. Croatian medical journal, 61. (1), 8-17. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:150598

Barišić, Anita, et al. "DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status." Croatian medical journal, vol. 61, br. 1, 2020, str. 8-17. https://urn.nsk.hr/urn:nbn:hr:184:150598

Barišić, Anita, Maja Kolak, Ana Peterlin, Nataša Tul, Milena Gašparović Krpina, Saša Ostojić, Borut Peterlin i Nina Pereza. "DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status." Croatian medical journal 61, br. 1 (2020): 8-17. https://urn.nsk.hr/urn:nbn:hr:184:150598

Barišić, A., et al. (2020) 'DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status', Croatian medical journal, 61(1), str. 8-17. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:150598 (Datum pristupa: 21.11.2024.)

Barišić A, Kolak M, Peterlin A, Tul N, Gašparović Krpina M, Ostojić S, i sur.. DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status. Croatian medical journal [Internet]. 2020. [pristupljeno 21.11.2024.];61(1):8-17. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:150598

A. Barišić, et al., "DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status", Croatian medical journal, vol. 61, br. 1, str. 8-17, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:150598. [Citirano: 21.11.2024.]

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Naslov (engleski)DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status
Naslov (engleski)DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.
AutorAnita Barišić
AutorMaja Kolak
AutorAna Peterlin
AutorNataša Tul
AutorMilena Gašparović Krpina
AutorSaša Ostojić
AutorBorut Peterlin
AutorNina Pereza
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Aim To evaluate the association between spontaneous preterm birth (SPTB) and DNA methyltransferase (DNMT)1, 3A, 3B, and 3L gene polymorphisms, and their contribution to the clinical characteristics of women with SPTB and their newborns. Methods This case-control study, conducted in 2018, enrolled 162 women with SPTB and 162 women with term delivery. DNMT1 rs2228611, DNMT3A rs1550117, DNMT3B rs1569686, DNMT3B rs2424913, and DNMT3L rs2070565 single nucleotide polymorphisms were genotyped using polymerase chain reaction and restriction fragment length polymorphism methods. The clinical characteristics included in the analysis were family history of preterm birth, maternal smoking, maternal age, gestational week at delivery, and fetal birth weight. Results DNMT gene polymorphisms were not significantly associated with SPTB. DNMT3B rs1569686 and rs2424913 minor alleles (T) were significantly more frequent in women with familial PTB than in women with non-familial PTB, increasing the odds for familial PTB 3.30 and 3.54 times under dominant genetic models. They were also significantly more frequent in women with SPTB who smoked before pregnancy, reaching the most significant association under additive genetic models (odds ratio 6.86, 95% confidence interval 2.25-20.86, P < 0.001 ; odds ratio 3.77, 95% confidence interval 1.36-10.52, P = 0.011, respectively). Conclusions DNMT3B rs1569686 and rs2424913 gene polymorphisms might be associated with positive family history of PTB and smoking status.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian medical journal
Brojčani podacivol. 61, br. 1, str. 8-17
p-ISSN0353-9504
URN:NBNurn:nbn:hr:184:150598
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1052692
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2020-03-05 07:25:01