prikaz prve stranice dokumenta DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status
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Scientific paper - Original scientific paper
DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status
Croatian medical journal, 61 (2020), 1; 8-17. urn:nbn:hr:184:150598
Barišić, Anita; Kolak, Maja; Peterlin, Ana; Tul, Nataša; Gašparović Krpina, Milena; Ostojić, Saša; Peterlin, Borut; Pereza, Nina

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Barišić, A., Kolak, M., Peterlin, A., Tul, N., Gašparović Krpina, M., Ostojić, S. ... Pereza, N. (2020). DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status. Croatian medical journal, 61. (1), 8-17. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:150598

Barišić, Anita, et al. "DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status." Croatian medical journal, vol. 61, no. 1, 2020, pp. 8-17. https://urn.nsk.hr/urn:nbn:hr:184:150598

Barišić, Anita, Maja Kolak, Ana Peterlin, Nataša Tul, Milena Gašparović Krpina, Saša Ostojić, Borut Peterlin and Nina Pereza. "DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status." Croatian medical journal 61, no. 1 (2020): 8-17. https://urn.nsk.hr/urn:nbn:hr:184:150598

Barišić, A., et al. (2020) 'DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status', Croatian medical journal, 61(1), pp. 8-17. Available at: https://urn.nsk.hr/urn:nbn:hr:184:150598 (Accessed 22 January 2025)

Barišić A, Kolak M, Peterlin A, Tul N, Gašparović Krpina M, Ostojić S, and sur.. DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status. Croatian medical journal [Internet]. 2020 [cited 2025 January 22];61(1):8-17. Available at: https://urn.nsk.hr/urn:nbn:hr:184:150598

A. Barišić, et al., "DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status", Croatian medical journal, vol. 61, no. 1, pp. 8-17, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:150598. [Accessed: 22 January 2025]

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Title (english)DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status
Title (english)DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.
AuthorAnita Barišić
AuthorMaja Kolak
AuthorAna Peterlin
AuthorNataša Tul
AuthorMilena Gašparović Krpina
AuthorSaša Ostojić
AuthorBorut Peterlin
AuthorNina Pereza
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Aim To evaluate the association between spontaneous preterm birth (SPTB) and DNA methyltransferase (DNMT)1, 3A, 3B, and 3L gene polymorphisms, and their contribution to the clinical characteristics of women with SPTB and their newborns. Methods This case-control study, conducted in 2018, enrolled 162 women with SPTB and 162 women with term delivery. DNMT1 rs2228611, DNMT3A rs1550117, DNMT3B rs1569686, DNMT3B rs2424913, and DNMT3L rs2070565 single nucleotide polymorphisms were genotyped using polymerase chain reaction and restriction fragment length polymorphism methods. The clinical characteristics included in the analysis were family history of preterm birth, maternal smoking, maternal age, gestational week at delivery, and fetal birth weight. Results DNMT gene polymorphisms were not significantly associated with SPTB. DNMT3B rs1569686 and rs2424913 minor alleles (T) were significantly more frequent in women with familial PTB than in women with non-familial PTB, increasing the odds for familial PTB 3.30 and 3.54 times under dominant genetic models. They were also significantly more frequent in women with SPTB who smoked before pregnancy, reaching the most significant association under additive genetic models (odds ratio 6.86, 95% confidence interval 2.25-20.86, P < 0.001 ; odds ratio 3.77, 95% confidence interval 1.36-10.52, P = 0.011, respectively). Conclusions DNMT3B rs1569686 and rs2424913 gene polymorphisms might be associated with positive family history of PTB and smoking status.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian medical journal
Numberingvol. 61, no. 1, pp. 8-17
p-ISSN0353-9504
URN:NBNurn:nbn:hr:184:150598
Publication2020
Document URLhttp://bib.irb.hr/1052692
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-03-05 07:25:01