prikaz prve stranice dokumenta Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
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Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
Genes and Development, 19 (2005), 24; 3070-3082. https://doi.org/10.1101/gad.359305
Šulić, Sanda; Panić, Linda; Barkić, Martina; Merčep, Mladen; Uzelac, Miljana; Volarević, Siniša

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Šulić, S., Panić, L., Barkić, M., Merčep, M., Uzelac, M. i Volarević, S. (2005). Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes and Development, 19. (24), 3070-3082. doi: 10.1101/gad.359305

Šulić, Sanda, et al. "Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response." Genes and Development, vol. 19, br. 24, 2005, str. 3070-3082. https://doi.org/10.1101/gad.359305

Šulić, Sanda, Linda Panić, Martina Barkić, Mladen Merčep, Miljana Uzelac i Siniša Volarević. "Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response." Genes and Development 19, br. 24 (2005): 3070-3082. https://doi.org/10.1101/gad.359305

Šulić, S., et al. (2005) 'Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response', Genes and Development, 19(24), str. 3070-3082. doi: 10.1101/gad.359305

Šulić S, Panić L, Barkić M, Merčep M, Uzelac M, Volarević S. Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes and Development [Internet]. 15.12.2005. [pristupljeno 06.12.2024.];19(24):3070-3082. doi: 10.1101/gad.359305

S. Šulić, L. Panić, M. Barkić, M. Merčep, M. Uzelac i S. Volarević, "Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response", Genes and Development, vol. 19, br. 24, str. 3070-3082, Prosinac 2005. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:633091. [Citirano: 06.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:633091
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Naslov (engleski)Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
AutorSanda Šulić
AutorLinda Panić
AutorMartina Barkić
AutorMladen Merčep
AutorMiljana Uzelac
MBZ: 187862
AutorSiniša Volarević
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za molekularnu medicinu i biotehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Ribosome biogenesis has been associated with regulation of cell growth and cell division, but the molecular mechanisms that integrate the effect of ribosome biogenesis on these processes in mammalian cells remain unknown. To study the effect of impaired ribosome functions in vivo, we conditionally deleted one or two alleles of the 40S ribosomal protein S6 gene in T cells in the mouse. While complete deletion of S6 abrogated T-cell development, hemizygous expression did not have any effect on T-cell maturation in the thymus, but inhibited the accumulation of T cells in the spleen and lymph nodes, as a result of their decreased survival in the peripheral lymphoid organs. Additionally, TCR-mediated stimulation of S6-heterozygous T cells induced a normal increase in their size, but cell cycle progression was impaired. Genetic inactivation of p53 tumor suppressor rescued development of S6-homozygous null thymocytes and proliferative defect of S6-heterozygous T cells. These results demonstrate the existence of a p53-dependent checkpoint mechanism that senses changes in the fidelity of the translational machinery to prevent aberrant cell division or eliminate defective T cells in vivo. Failure to activate this checkpoint response could potentially lead to a development of pathological processes such as tumors and autoimmune disease.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes and Development
Brojčani podacivol. 19, br. 24, str. 3070-3082
p-ISSN0890-9369
e-ISSN1549-5477
DOIhttps://doi.org/10.1101/gad.359305
URN:NBNurn:nbn:hr:184:633091
Datum objave publikacije2005-12-15
URL dokumentahttp://www.genesdev.org/cgi/doi/10.1101/gad.359305
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-29 22:37:25