prikaz prve stranice dokumenta Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
  Download
PDF 731.1 KB
Scientific paper - Original scientific paper
Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
Genes and Development, 19 (2005), 24; 3070-3082. https://doi.org/10.1101/gad.359305
Šulić, Sanda; Panić, Linda; Barkić, Martina; Merčep, Mladen; Uzelac, Miljana; Volarević, Siniša

Cite this document

Šulić, S., Panić, L., Barkić, M., Merčep, M., Uzelac, M. & Volarević, S. (2005). Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes and Development, 19. (24), 3070-3082. doi: 10.1101/gad.359305

Šulić, Sanda, et al. "Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response." Genes and Development, vol. 19, no. 24, 2005, pp. 3070-3082. https://doi.org/10.1101/gad.359305

Šulić, Sanda, Linda Panić, Martina Barkić, Mladen Merčep, Miljana Uzelac and Siniša Volarević. "Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response." Genes and Development 19, no. 24 (2005): 3070-3082. https://doi.org/10.1101/gad.359305

Šulić, S., et al. (2005) 'Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response', Genes and Development, 19(24), pp. 3070-3082. doi: 10.1101/gad.359305

Šulić S, Panić L, Barkić M, Merčep M, Uzelac M, Volarević S. Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes and Development [Internet]. 2005 December 15 [cited 2024 November 11];19(24):3070-3082. doi: 10.1101/gad.359305

S. Šulić, L. Panić, M. Barkić, M. Merčep, M. Uzelac and S. Volarević, "Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response", Genes and Development, vol. 19, no. 24, pp. 3070-3082, December 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:633091. [Accessed: 11 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
AuthorSanda Šulić
AuthorLinda Panić
AuthorMartina Barkić
AuthorMladen Merčep
AuthorMiljana Uzelac
MBZ: 187862
AuthorSiniša Volarević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Molecular Medicine and Biotechnology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Ribosome biogenesis has been associated with regulation of cell growth and cell division, but the molecular mechanisms that integrate the effect of ribosome biogenesis on these processes in mammalian cells remain unknown. To study the effect of impaired ribosome functions in vivo, we conditionally deleted one or two alleles of the 40S ribosomal protein S6 gene in T cells in the mouse. While complete deletion of S6 abrogated T-cell development, hemizygous expression did not have any effect on T-cell maturation in the thymus, but inhibited the accumulation of T cells in the spleen and lymph nodes, as a result of their decreased survival in the peripheral lymphoid organs. Additionally, TCR-mediated stimulation of S6-heterozygous T cells induced a normal increase in their size, but cell cycle progression was impaired. Genetic inactivation of p53 tumor suppressor rescued development of S6-homozygous null thymocytes and proliferative defect of S6-heterozygous T cells. These results demonstrate the existence of a p53-dependent checkpoint mechanism that senses changes in the fidelity of the translational machinery to prevent aberrant cell division or eliminate defective T cells in vivo. Failure to activate this checkpoint response could potentially lead to a development of pathological processes such as tumors and autoimmune disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleGenes and Development
Numberingvol. 19, no. 24, pp. 3070-3082
p-ISSN0890-9369
e-ISSN1549-5477
DOIhttps://doi.org/10.1101/gad.359305
URN:NBNurn:nbn:hr:184:633091
Publication2005-12-15
Document URLhttp://www.genesdev.org/cgi/doi/10.1101/gad.359305
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-29 22:37:25