prikaz prve stranice dokumenta Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus
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Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus
Journal of Experimental Medicine, 166 (1987), 3; 668-677. https://doi.org/10.1084/jem.166.3.668
Volkmer, Hansjürgen; Bertholet, Christine; Jonjić, Stipan; Wittek, Riccardo; Koszinowski, Ulrich H.

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Volkmer, H., Bertholet, C., Jonjić, S., Wittek, R. i Koszinowski, U. H. (1987). Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus. Journal of Experimental Medicine, 166. (3), 668-677. doi: 10.1084/jem.166.3.668

Volkmer, Hansjürgen, et al. "Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus." Journal of Experimental Medicine, vol. 166, br. 3, 1987, str. 668-677. https://doi.org/10.1084/jem.166.3.668

Volkmer, Hansjürgen, Christine Bertholet, Stipan Jonjić, Riccardo Wittek i Ulrich H. Koszinowski. "Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus." Journal of Experimental Medicine 166, br. 3 (1987): 668-677. https://doi.org/10.1084/jem.166.3.668

Volkmer, H., et al. (1987) 'Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus', Journal of Experimental Medicine, 166(3), str. 668-677. doi: 10.1084/jem.166.3.668

Volkmer H, Bertholet C, Jonjić S, Wittek R, Koszinowski UH. Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus. Journal of Experimental Medicine [Internet]. 1987. [pristupljeno 08.05.2024.];166(3):668-677. doi: 10.1084/jem.166.3.668

H. Volkmer, C. Bertholet, S. Jonjić, R. Wittek i U. H. Koszinowski, "Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus", Journal of Experimental Medicine, vol. 166, br. 3, str. 668-677, 1987. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:800512. [Citirano: 08.05.2024.]

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Naslov (engleski)Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus
AutorHansjürgen Volkmer
AutorChristine Bertholet
AutorStipan Jonjić
AutorRiccardo Wittek
AutorUlrich H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The murine immediate-early (IE) protein pp89 is a nonstructural virus- encoded phosphoprotein residing in the nucleus of infected cells, where it acts as transcriptional activator. Frequency analysis has shown that in BALB/c mice the majority of virus-specific CTL recognize IE antigens. The present study was performed to assess whether pp89 causes membrane antigen expression detected by IE-specific CTL. Site-directed mutagenesis has been used to delete the introns from gene ieI, encoding pp89, for subsequent integration of the continuous coding sequence into the vaccinia virus genome. After infection with the vaccinia recombinant, the authentic pp89 was expressed in cells that became susceptible to lysis by an IE-specific CTL clone. Priming of mice with the vaccinia recombinant sensitized polyclonal CTL that recognized MCMV- infected cells and transfected cells expressing pp89. Thus, a herpesviral IE polypeptide with essential function in viral transcriptional regulation can also serve as a dominant antigen for the specific CTL response of the host.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 166, br. 3, str. 668-677
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.166.3.668
URN:NBNurn:nbn:hr:184:800512
Datum objave publikacije1987
URL dokumentahttp://jem.rupress.org/content/166/3/668.long
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-29 21:51:30