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Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity
Clinical & experimental metastasis, 28 (2011), 5; 451-462. https://doi.org/10.1007/s10585-011-9383-y
Radosavljević, Gordana; Jovanović, Ivan; Majstorović, Ivana; Mitrović, Maja; Lisnić, Vanda Juranić; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.

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Radosavljević, G., Jovanović, I., Majstorović, I., Mitrović, M., Lisnić, V. J., Arsenijević, N. ... Lukić, M. L. (2011). Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. Clinical & experimental metastasis, 28. (5), 451-462. doi: 10.1007/s10585-011-9383-y

Radosavljević, Gordana, et al. "Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity." Clinical & experimental metastasis, vol. 28, br. 5, 2011, str. 451-462. https://doi.org/10.1007/s10585-011-9383-y

Radosavljević, Gordana, Ivan Jovanović, Ivana Majstorović, Maja Mitrović, Vanda Juranić Lisnić, Nebojša Arsenijević, Stipan Jonjić i Miodrag L. Lukić. "Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity." Clinical & experimental metastasis 28, br. 5 (2011): 451-462. https://doi.org/10.1007/s10585-011-9383-y

Radosavljević, G., et al. (2011) 'Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity', Clinical & experimental metastasis, 28(5), str. 451-462. doi: 10.1007/s10585-011-9383-y

Radosavljević G, Jovanović I, Majstorović I, Mitrović M, Lisnić VJ, Arsenijević N, i sur.. Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. Clinical & experimental metastasis [Internet]. 26.03.2011. [pristupljeno 13.11.2024.];28(5):451-462. doi: 10.1007/s10585-011-9383-y

G. Radosavljević, et al., "Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity", Clinical & experimental metastasis, vol. 28, br. 5, str. 451-462, Ožujak 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:051018. [Citirano: 13.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:051018
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Naslov (engleski)Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity
AutorGordana Radosavljević
AutorIvan Jovanović
AutorIvana Majstorović
AutorMaja Mitrović
AutorVanda Juranić Lisnić
AutorNebojša Arsenijević
AutorStipan Jonjić
AutorMiodrag L. Lukić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Galectin-3, a β galactoside-binding lectin, plays an important role in the processes relevant to tumorigenesis such as malignant cell transformation, invasion and metastasis. We have investigated whether deletion of Galectin-3 in the host affects the metastasis of B16F1 malignant melanoma. Galectin-3-deficient (Gal-3(-/-)) mice are more resistant to metastatic malignant melanoma as evaluated by number and size of metastatic colonies in the lung. In vitro assays showed lower number of attached malignant cells in the tissue section derived from Gal-3(-/-) mice. Furthermore, lack of Galectin-3 correlates with higher serum levels of IFN-γ and IL-17 in tumor bearing hosts. Interestingly, spleens of Gal-3(-/-) mice have lower number of Foxp3(+) T cells after injection of B16F1 melanoma cells. Finally, we found that while CD8(+) T cell and adherent cell cytotoxicity were similar, there was greater cytotoxic activity of splenic NK cells of Gal-3(-/-) mice compared with "wild-type" (Gal-3( +/+ )) mice. Despite the reduction in total number of CD3ε(-)NK1.1(+), Gal-3(-/-) mice constitutively have a significantly higher percentage of effective cytotoxic CD27(high)CD11b(high) NK cells as well as the percentage of immature CD27(high)CD11b(low) NK cells. In contrast, CD27(low)CD11b(high) less functionally exhausted NK cells and NK cells bearing inhibitory KLRG1 receptor were more numerous in Gal-3( +/+ ) mice. It appears that lack of Galectin-3 affects tumor metastasis by at least two independent mechanisms: by a decrease in binding of melanoma cells onto target tissue and by enhanced NK-mediated anti-tumor response suggesting that Galectin-3 may be considered as therapeutic target.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical & experimental metastasis
Brojčani podacivol. 28, br. 5, str. 451-462
p-ISSN0262-0898
e-ISSN1573-7276
DOIhttps://doi.org/10.1007/s10585-011-9383-y
URN:NBNurn:nbn:hr:184:051018
Datum objave publikacije2011-03-26
Datum objave publikacije2011-06
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://link.springer.com/10.1007/s10585-011-9383-y
Vrsta resursaTekst
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Datum i vrijeme pohrane2018-11-09 08:38:44