prikaz prve stranice dokumenta Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity
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Scientific paper - Original scientific paper
Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity
Clinical & experimental metastasis, 28 (2011), 5; 451-462. https://doi.org/10.1007/s10585-011-9383-y
Radosavljević, Gordana; Jovanović, Ivan; Majstorović, Ivana; Mitrović, Maja; Lisnić, Vanda Juranić; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.

Cite this document

Radosavljević, G., Jovanović, I., Majstorović, I., Mitrović, M., Lisnić, V. J., Arsenijević, N. ... Lukić, M. L. (2011). Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. Clinical & experimental metastasis, 28. (5), 451-462. doi: 10.1007/s10585-011-9383-y

Radosavljević, Gordana, et al. "Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity." Clinical & experimental metastasis, vol. 28, no. 5, 2011, pp. 451-462. https://doi.org/10.1007/s10585-011-9383-y

Radosavljević, Gordana, Ivan Jovanović, Ivana Majstorović, Maja Mitrović, Vanda Juranić Lisnić, Nebojša Arsenijević, Stipan Jonjić and Miodrag L. Lukić. "Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity." Clinical & experimental metastasis 28, no. 5 (2011): 451-462. https://doi.org/10.1007/s10585-011-9383-y

Radosavljević, G., et al. (2011) 'Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity', Clinical & experimental metastasis, 28(5), pp. 451-462. doi: 10.1007/s10585-011-9383-y

Radosavljević G, Jovanović I, Majstorović I, Mitrović M, Lisnić VJ, Arsenijević N, and sur.. Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. Clinical & experimental metastasis [Internet]. 2011 March 26 [cited 2024 November 22];28(5):451-462. doi: 10.1007/s10585-011-9383-y

G. Radosavljević, et al., "Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity", Clinical & experimental metastasis, vol. 28, no. 5, pp. 451-462, March 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:051018. [Accessed: 22 November 2024]

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Metadata
Title (english)Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity
AuthorGordana Radosavljević
AuthorIvan Jovanović
AuthorIvana Majstorović
AuthorMaja Mitrović
AuthorVanda Juranić Lisnić
AuthorNebojša Arsenijević
AuthorStipan Jonjić
AuthorMiodrag L. Lukić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Galectin-3, a β galactoside-binding lectin, plays an important role in the processes relevant to tumorigenesis such as malignant cell transformation, invasion and metastasis. We have investigated whether deletion of Galectin-3 in the host affects the metastasis of B16F1 malignant melanoma. Galectin-3-deficient (Gal-3(-/-)) mice are more resistant to metastatic malignant melanoma as evaluated by number and size of metastatic colonies in the lung. In vitro assays showed lower number of attached malignant cells in the tissue section derived from Gal-3(-/-) mice. Furthermore, lack of Galectin-3 correlates with higher serum levels of IFN-γ and IL-17 in tumor bearing hosts. Interestingly, spleens of Gal-3(-/-) mice have lower number of Foxp3(+) T cells after injection of B16F1 melanoma cells. Finally, we found that while CD8(+) T cell and adherent cell cytotoxicity were similar, there was greater cytotoxic activity of splenic NK cells of Gal-3(-/-) mice compared with "wild-type" (Gal-3( +/+ )) mice. Despite the reduction in total number of CD3ε(-)NK1.1(+), Gal-3(-/-) mice constitutively have a significantly higher percentage of effective cytotoxic CD27(high)CD11b(high) NK cells as well as the percentage of immature CD27(high)CD11b(low) NK cells. In contrast, CD27(low)CD11b(high) less functionally exhausted NK cells and NK cells bearing inhibitory KLRG1 receptor were more numerous in Gal-3( +/+ ) mice. It appears that lack of Galectin-3 affects tumor metastasis by at least two independent mechanisms: by a decrease in binding of melanoma cells onto target tissue and by enhanced NK-mediated anti-tumor response suggesting that Galectin-3 may be considered as therapeutic target.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleClinical & experimental metastasis
Numberingvol. 28, no. 5, pp. 451-462
p-ISSN0262-0898
e-ISSN1573-7276
DOIhttps://doi.org/10.1007/s10585-011-9383-y
URN:NBNurn:nbn:hr:184:051018
Publication2011-03-26
Publication2011-06
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://link.springer.com/10.1007/s10585-011-9383-y
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2018-11-09 08:38:44