prikaz prve stranice dokumenta Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
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Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
The Journal of Experimental Medicine, 207 (2010), 12; 2663-2673. https://doi.org/10.1084/jem.20100921
Babić, Marina; Pyzik, Michal; Zafirova, Biljana; Mitrović, Maja; Butorac, Višnja; Lanier, Lewis L.; Krmpotić, Astrid; Vidal, Silvia M.; Jonjić, Stipan

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Babić, M., Pyzik, M., Zafirova, B., Mitrović, M., Butorac, V., Lanier, L. L. ... Jonjić, S. (2010). Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo. The Journal of Experimental Medicine, 207. (12), 2663-2673. doi: 10.1084/jem.20100921

Babić, Marina, et al. "Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo." The Journal of Experimental Medicine, vol. 207, br. 12, 2010, str. 2663-2673. https://doi.org/10.1084/jem.20100921

Babić, Marina, Michal Pyzik, Biljana Zafirova, Maja Mitrović, Višnja Butorac, Lewis L. Lanier, Astrid Krmpotić, Silvia M. Vidal i Stipan Jonjić. "Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo." The Journal of Experimental Medicine 207, br. 12 (2010): 2663-2673. https://doi.org/10.1084/jem.20100921

Babić, M., et al. (2010) 'Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo', The Journal of Experimental Medicine, 207(12), str. 2663-2673. doi: 10.1084/jem.20100921

Babić M, Pyzik M, Zafirova B, Mitrović M, Butorac V, Lanier LL, i sur.. Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo. The Journal of Experimental Medicine [Internet]. 22.11.2010. [pristupljeno 03.12.2024.];207(12):2663-2673. doi: 10.1084/jem.20100921

M. Babić, et al., "Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo", The Journal of Experimental Medicine, vol. 207, br. 12, str. 2663-2673, Studeni 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:321399. [Citirano: 03.12.2024.]

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Naslov (engleski)Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
AutorMarina Babić
AutorMichal Pyzik
AutorBiljana Zafirova
AutorMaja Mitrović
AutorVišnja Butorac
AutorLewis L. Lanier
AutorAstrid Krmpotić
AutorSilvia M. Vidal
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegaloviruses (CMVs) are renowned for interfering with the immune system of their hosts. To sidestep antigen presentation and destruction by CD8(+) T cells, these viruses reduce expression of major histocompatibility complex class I (MHC I) molecules. However, this process sensitizes the virus-infected cells to natural killer (NK) cell-mediated killing via the "missing self" axis. Mouse cytomegalovirus (MCMV) uses m152 and m06 encoded proteins to inhibit surface expression of MHC I molecules. In addition, it encodes another protein, m04, which forms complexes with MHC I and escorts them to the cell surface. This mechanism is believed to prevent NK cell activation and killing by restoring the "self" signature and allowing the engagement of inhibitory Ly49 receptors on NK cells. Here we show that MCMV lacking m04 was attenuated in an NK cell- and MHC I-dependent manner. NK cell-mediated control of the infection was dependent on the presence of NK cell subsets expressing different inhibitory Ly49 receptors. In addition to providing evidence for immunoevasion strategies used by CMVs to avoid NK cell control via the missing-self pathway, our study is the first to demonstrate that missing self-dependent NK cell activation is biologically relevant in the protection against viral infection in vivo.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Journal of Experimental Medicine
Brojčani podacivol. 207, br. 12, str. 2663-2673
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20100921
URN:NBNurn:nbn:hr:184:321399
Datum objave publikacije2010-11-22
Datum objave publikacije2010-11-15
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 062-0621261-1268
Naziv (hrvatski): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://www.jem.org/lookup/doi/10.1084/jem.20100921
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 3.0 (CC BY-NC-ND 3.0)
Datum i vrijeme pohrane2018-11-08 23:18:28