prikaz prve stranice dokumenta Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
  Download
PDF 2.09 MB
Scientific paper - Original scientific paper
Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
The Journal of Experimental Medicine, 207 (2010), 12; 2663-2673. https://doi.org/10.1084/jem.20100921
Babić, Marina; Pyzik, Michal; Zafirova, Biljana; Mitrović, Maja; Butorac, Višnja; Lanier, Lewis L.; Krmpotić, Astrid; Vidal, Silvia M.; Jonjić, Stipan

Cite this document

Babić, M., Pyzik, M., Zafirova, B., Mitrović, M., Butorac, V., Lanier, L. L. ... Jonjić, S. (2010). Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo. The Journal of Experimental Medicine, 207. (12), 2663-2673. doi: 10.1084/jem.20100921

Babić, Marina, et al. "Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo." The Journal of Experimental Medicine, vol. 207, no. 12, 2010, pp. 2663-2673. https://doi.org/10.1084/jem.20100921

Babić, Marina, Michal Pyzik, Biljana Zafirova, Maja Mitrović, Višnja Butorac, Lewis L. Lanier, Astrid Krmpotić, Silvia M. Vidal and Stipan Jonjić. "Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo." The Journal of Experimental Medicine 207, no. 12 (2010): 2663-2673. https://doi.org/10.1084/jem.20100921

Babić, M., et al. (2010) 'Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo', The Journal of Experimental Medicine, 207(12), pp. 2663-2673. doi: 10.1084/jem.20100921

Babić M, Pyzik M, Zafirova B, Mitrović M, Butorac V, Lanier LL, and sur.. Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo. The Journal of Experimental Medicine [Internet]. 2010 November 22 [cited 2024 December 25];207(12):2663-2673. doi: 10.1084/jem.20100921

M. Babić, et al., "Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo", The Journal of Experimental Medicine, vol. 207, no. 12, pp. 2663-2673, November 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:321399. [Accessed: 25 December 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
AuthorMarina Babić
AuthorMichal Pyzik
AuthorBiljana Zafirova
AuthorMaja Mitrović
AuthorVišnja Butorac
AuthorLewis L. Lanier
AuthorAstrid Krmpotić
AuthorSilvia M. Vidal
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegaloviruses (CMVs) are renowned for interfering with the immune system of their hosts. To sidestep antigen presentation and destruction by CD8(+) T cells, these viruses reduce expression of major histocompatibility complex class I (MHC I) molecules. However, this process sensitizes the virus-infected cells to natural killer (NK) cell-mediated killing via the "missing self" axis. Mouse cytomegalovirus (MCMV) uses m152 and m06 encoded proteins to inhibit surface expression of MHC I molecules. In addition, it encodes another protein, m04, which forms complexes with MHC I and escorts them to the cell surface. This mechanism is believed to prevent NK cell activation and killing by restoring the "self" signature and allowing the engagement of inhibitory Ly49 receptors on NK cells. Here we show that MCMV lacking m04 was attenuated in an NK cell- and MHC I-dependent manner. NK cell-mediated control of the infection was dependent on the presence of NK cell subsets expressing different inhibitory Ly49 receptors. In addition to providing evidence for immunoevasion strategies used by CMVs to avoid NK cell control via the missing-self pathway, our study is the first to demonstrate that missing self-dependent NK cell activation is biologically relevant in the protection against viral infection in vivo.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThe Journal of Experimental Medicine
Numberingvol. 207, no. 12, pp. 2663-2673
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20100921
URN:NBNurn:nbn:hr:184:321399
Publication2010-11-22
Publication2010-11-15
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0621261-1268
Title (croatian): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://www.jem.org/lookup/doi/10.1084/jem.20100921
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) icon
Created on2018-11-08 23:18:28