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CEACAM1-Mediated Inhibition of Virus Production
Cell Reports, 15 (2016), 11; 2331-2339. https://doi.org/10.1016/j.celrep.2016.05.036
Vitenshtein, Alon; Weisblum, Yiska; Hauka, Sebastian; Halenius, Anne; Oiknine-Djian, Esther; Tsukerman, Pinchas; Bauman, Yoav; Bar-On, Yotam; Stern-Ginossar, Noam; Enk, Jonatan; Ortenberg, Rona; Tai, Julie; Markel, Gal; Blumberg, Richard S.; Hengel, Hartmut; Jonjić, Stipan; Wolf, Dana G.; Adler, Heiko; Kammerer, Robert; Mandelboim, Ofer Više autora...

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Vitenshtein, A., Weisblum, Y., Hauka, S., Halenius, A., Oiknine Djian, E., Tsukerman, P. ... Mandelboim, O. (2016). CEACAM1-Mediated Inhibition of Virus Production. Cell Reports, 15. (11), 2331-2339. doi: 10.1016/j.celrep.2016.05.036

Vitenshtein, Alon, et al. "CEACAM1-Mediated Inhibition of Virus Production." Cell Reports, vol. 15, br. 11, 2016, str. 2331-2339. https://doi.org/10.1016/j.celrep.2016.05.036

Vitenshtein, Alon, Yiska Weisblum, Sebastian Hauka, Anne Halenius, Esther Oiknine Djian, Pinchas Tsukerman, Yoav Bauman, et al. "CEACAM1-Mediated Inhibition of Virus Production." Cell Reports 15, br. 11 (2016): 2331-2339. https://doi.org/10.1016/j.celrep.2016.05.036

Vitenshtein, A., et al. (2016) 'CEACAM1-Mediated Inhibition of Virus Production', Cell Reports, 15(11), str. 2331-2339. doi: 10.1016/j.celrep.2016.05.036

Vitenshtein A, Weisblum Y, Hauka S, Halenius A, Oiknine Djian E, Tsukerman P, i sur.. CEACAM1-Mediated Inhibition of Virus Production. Cell Reports [Internet]. 06.2016. [pristupljeno 12.11.2024.];15(11):2331-2339. doi: 10.1016/j.celrep.2016.05.036

A. Vitenshtein, et al., "CEACAM1-Mediated Inhibition of Virus Production", Cell Reports, vol. 15, br. 11, str. 2331-2339, Lipanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:008420. [Citirano: 12.11.2024.]

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Naslov (engleski)CEACAM1-Mediated Inhibition of Virus Production
AutorAlon Vitenshtein
AutorYiska Weisblum
AutorSebastian Hauka
AutorAnne Halenius
AutorEsther Oiknine-Djian
AutorPinchas Tsukerman
AutorYoav Bauman
AutorYotam Bar-On
AutorNoam Stern-Ginossar
AutorJonatan Enk
AutorRona Ortenberg
AutorJulie Tai
AutorGal Markel
AutorRichard S. Blumberg
AutorHartmut Hengel
AutorStipan Jonjić
AutorDana G. Wolf
AutorHeiko Adler
AutorRobert Kammerer
AutorOfer Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respective DNA and RNA innate sensors, IFI16 and RIG-I. This induction is mediated by IRF3, which bound to an ISRE element present in the human, but not mouse, CEACAM1 promoter. Furthermore, we demonstrate that, upon induction, CEACAM1 suppresses both HCMV and influenza viruses in an SHP2-dependent process and achieves this broad antiviral efficacy by suppressing mTOR-mediated protein biosynthesis. Finally, we show that CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCell Reports
Brojčani podacivol. 15, br. 11, str. 2331-2339
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2016.05.036
URN:NBNurn:nbn:hr:184:008420
Datum objave publikacije2016-06
ProjektŠifra: 320473
Naziv (engleski): Recognition of bacteria by NK cells
Kratica: BACNK
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 316655
Naziv (engleski): Training network for next generation vaccinologists
Kratica: VACTRAIN
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S2211124716306192
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-07 09:25:55