prikaz prve stranice dokumenta Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons
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Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons
PLOS Pathogens, 11 (2015), 4; e1004774. https://doi.org/10.1371/journal.ppat.1004774
Bradford, Russell; Yoo, Young-Gun; Golemac, Mijo; Pugel Pernjak, Ester; Jonjić, Stipan; Britt, William J.

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Bradford, R., Yoo, Y. G., Golemac, M., Pugel Pernjak, E., Jonjić, S. i Britt, W. J. (2015). Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons. PLOS Pathogens, 11. (4). doi: 10.1371/journal.ppat.1004774

Bradford, Russell, et al. "Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons." PLOS Pathogens, vol. 11, br. 4, 2015. https://doi.org/10.1371/journal.ppat.1004774

Bradford, Russell, Young Gun Yoo, Mijo Golemac, Ester Pugel Pernjak, Stipan Jonjić i William J. Britt. "Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons." PLOS Pathogens 11, br. 4 (2015). https://doi.org/10.1371/journal.ppat.1004774

Bradford, R., et al. (2015) 'Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons', PLOS Pathogens, 11(4). doi: 10.1371/journal.ppat.1004774

Bradford R, Yoo YG, Golemac M, Pugel Pernjak E, Jonjić S, Britt WJ. Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons. PLOS Pathogens [Internet]. 13.04.2015. [pristupljeno 14.11.2024.];11(4). doi: 10.1371/journal.ppat.1004774

R. Bradford, Y. G. Yoo, M. Golemac, E. Pugel Pernjak, S. Jonjić i W. J. Britt, "Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons", PLOS Pathogens, vol. 11, br. 4, Travanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:767729. [Citirano: 14.11.2024.]

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Naslov (engleski)Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons
AutorRussell Bradford
AutorYoung-Gun Yoo
AutorMijo Golemac
AutorEster Pugel Pernjak
AutorStipan Jonjić
AutorWilliam J. Britt
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Congenital human cytomegalovirus (HCMV) occurs in 0.5–1% of live births and approximately 10% of infected infants develop hearing loss. The mechanism(s) of hearing loss remain unknown. We developed a murine model of CMV induced hearing loss in which murine cytomegalovirus (MCMV) infection of newborn mice leads to hematogenous spread of virus to the inner ear, induction of inflammatory responses, and hearing loss. Characteristics of the hearing loss described in infants with congenital HCMV infection were observed including, delayed onset, progressive hearing loss, and unilateral hearing loss in this model and, these characteristics were viral inoculum dependent. Viral antigens were present in the inner ear as were CD3+ mononuclear cells in the spiral ganglion and stria vascularis. Spiral ganglion neuron density was decreased after infection, thus providing a mechanism for hearing loss. The lack of significant inner ear histopathology and persistence of inflammation in cochlea of mice with hearing loss raised the possibility that inflammation was a major component of the mechanism(s) of hearing loss in MCMV infected mice.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLOS Pathogens
Brojčani podacivol. 11, br. 4, e1004774
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1004774
URN:NBNurn:nbn:hr:184:767729
Datum objave publikacije2015-04-13
URL dokumentahttps://dx.plos.org/10.1371/journal.ppat.1004774
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-10-31 08:34:12