prikaz prve stranice dokumenta Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons
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Scientific paper - Original scientific paper
Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons
PLOS Pathogens, 11 (2015), 4; e1004774. https://doi.org/10.1371/journal.ppat.1004774
Bradford, Russell; Yoo, Young-Gun; Golemac, Mijo; Pugel Pernjak, Ester; Jonjić, Stipan; Britt, William J.

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Bradford, R., Yoo, Y. G., Golemac, M., Pugel Pernjak, E., Jonjić, S. & Britt, W. J. (2015). Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons. PLOS Pathogens, 11. (4). doi: 10.1371/journal.ppat.1004774

Bradford, Russell, et al. "Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons." PLOS Pathogens, vol. 11, no. 4, 2015. https://doi.org/10.1371/journal.ppat.1004774

Bradford, Russell, Young Gun Yoo, Mijo Golemac, Ester Pugel Pernjak, Stipan Jonjić and William J. Britt. "Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons." PLOS Pathogens 11, no. 4 (2015). https://doi.org/10.1371/journal.ppat.1004774

Bradford, R., et al. (2015) 'Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons', PLOS Pathogens, 11(4). doi: 10.1371/journal.ppat.1004774

Bradford R, Yoo YG, Golemac M, Pugel Pernjak E, Jonjić S, Britt WJ. Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons. PLOS Pathogens [Internet]. 2015 April 13 [cited 2024 November 15];11(4). doi: 10.1371/journal.ppat.1004774

R. Bradford, Y. G. Yoo, M. Golemac, E. Pugel Pernjak, S. Jonjić and W. J. Britt, "Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons", PLOS Pathogens, vol. 11, no. 4, April 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:767729. [Accessed: 15 November 2024]

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Metadata
Title (english)Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons
AuthorRussell Bradford
AuthorYoung-Gun Yoo
AuthorMijo Golemac
AuthorEster Pugel Pernjak
AuthorStipan Jonjić
AuthorWilliam J. Britt
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Congenital human cytomegalovirus (HCMV) occurs in 0.5–1% of live births and approximately 10% of infected infants develop hearing loss. The mechanism(s) of hearing loss remain unknown. We developed a murine model of CMV induced hearing loss in which murine cytomegalovirus (MCMV) infection of newborn mice leads to hematogenous spread of virus to the inner ear, induction of inflammatory responses, and hearing loss. Characteristics of the hearing loss described in infants with congenital HCMV infection were observed including, delayed onset, progressive hearing loss, and unilateral hearing loss in this model and, these characteristics were viral inoculum dependent. Viral antigens were present in the inner ear as were CD3+ mononuclear cells in the spiral ganglion and stria vascularis. Spiral ganglion neuron density was decreased after infection, thus providing a mechanism for hearing loss. The lack of significant inner ear histopathology and persistence of inflammation in cochlea of mice with hearing loss raised the possibility that inflammation was a major component of the mechanism(s) of hearing loss in MCMV infected mice.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLOS Pathogens
Numberingvol. 11, no. 4, e1004774
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1004774
URN:NBNurn:nbn:hr:184:767729
Publication2015-04-13
Document URLhttps://dx.plos.org/10.1371/journal.ppat.1004774
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-10-31 08:34:12