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The Role of Iron and Iron Overload in Chronic Liver Disease
Medical Science Monitor, 22 (2016); 2144-2151. https://doi.org/10.12659/MSM.896494
Milić, Sandra; Mikolašević, Ivana; Orlić, Lidija; Devčić, Edita; Starčević-Čizmarević, Nada; Štimac, Davor; Kapović, Miljenko; Ristić, Smiljana

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Milić, S., Mikolašević, I., Orlić, L., Devčić, E., Starčević Čizmarević, N., Štimac, D. ... Ristić, S. (2016). The Role of Iron and Iron Overload in Chronic Liver Disease. Medical Science Monitor, 22., 2144-2151. doi: 10.12659/MSM.896494

Milić, Sandra, et al. "The Role of Iron and Iron Overload in Chronic Liver Disease." Medical Science Monitor, vol. 22, 2016, str. 2144-2151. https://doi.org/10.12659/MSM.896494

Milić, Sandra, Ivana Mikolašević, Lidija Orlić, Edita Devčić, Nada Starčević Čizmarević, Davor Štimac, Miljenko Kapović i Smiljana Ristić. "The Role of Iron and Iron Overload in Chronic Liver Disease." Medical Science Monitor 22 (2016): 2144-2151. https://doi.org/10.12659/MSM.896494

Milić, S., et al. (2016) 'The Role of Iron and Iron Overload in Chronic Liver Disease', Medical Science Monitor, 22, str. 2144-2151. doi: 10.12659/MSM.896494

Milić S, Mikolašević I, Orlić L, Devčić E, Starčević Čizmarević N, Štimac D, i sur.. The Role of Iron and Iron Overload in Chronic Liver Disease. Medical Science Monitor [Internet]. 22.06.2016. [pristupljeno 06.12.2024.];22:2144-2151. doi: 10.12659/MSM.896494

S. Milić, et al., "The Role of Iron and Iron Overload in Chronic Liver Disease", Medical Science Monitor, vol. 22, str. 2144-2151, Lipanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:825437. [Citirano: 06.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:825437
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Podaci o radu
Naslov (engleski)The Role of Iron and Iron Overload in Chronic Liver Disease
AutorSandra Milić
AutorIvana Mikolašević
AutorLidija Orlić
AutorEdita Devčić
AutorNada Starčević-Čizmarević
AutorDavor Štimac
AutorMiljenko Kapović
AutorSmiljana Ristić
MBZ: 142283
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
The liver plays a major role in iron homeostasis; thus, in patients with chronic liver disease, iron regulation may be disturbed. Higher iron levels are present not only in patients with hereditary hemochromatosis, but also in those with alcoholic liver disease, nonalcoholic fatty liver disease, and hepatitis C viral infection. Chronic liver disease decreases the synthetic functions of the liver, including the production of hepcidin, a key protein in iron metabolism. Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-transferrin-bound iron in the bloodstream. Iron combined with reactive oxygen species leads to an increase in hydroxyl radicals, which are responsible for phospholipid peroxidation, oxidation of amino acid side chains, DNA strain breaks, and protein fragmentation. Iron-induced cellular damage may be prevented by regulating the production of hepcidin or by administering hepcidin agonists. Both of these methods have yielded successful results in mouse models.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical Science Monitor
Brojčani podacivol. 22, str. 2144-2151
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.896494
URN:NBNurn:nbn:hr:184:825437
Datum objave publikacije2016-06-22
URL dokumentahttp://www.medscimonit.com/abstract/index/idArt/896494
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-07-31 10:15:30