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Scientific paper - Review paper
The Role of Iron and Iron Overload in Chronic Liver Disease
Medical Science Monitor, 22 (2016); 2144-2151. https://doi.org/10.12659/MSM.896494
Milić, Sandra; Mikolašević, Ivana; Orlić, Lidija; Devčić, Edita; Starčević-Čizmarević, Nada; Štimac, Davor; Kapović, Miljenko; Ristić, Smiljana

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Milić, S., Mikolašević, I., Orlić, L., Devčić, E., Starčević Čizmarević, N., Štimac, D. ... Ristić, S. (2016). The Role of Iron and Iron Overload in Chronic Liver Disease. Medical Science Monitor, 22., 2144-2151. doi: 10.12659/MSM.896494

Milić, Sandra, et al. "The Role of Iron and Iron Overload in Chronic Liver Disease." Medical Science Monitor, vol. 22, 2016, pp. 2144-2151. https://doi.org/10.12659/MSM.896494

Milić, Sandra, Ivana Mikolašević, Lidija Orlić, Edita Devčić, Nada Starčević Čizmarević, Davor Štimac, Miljenko Kapović and Smiljana Ristić. "The Role of Iron and Iron Overload in Chronic Liver Disease." Medical Science Monitor 22 (2016): 2144-2151. https://doi.org/10.12659/MSM.896494

Milić, S., et al. (2016) 'The Role of Iron and Iron Overload in Chronic Liver Disease', Medical Science Monitor, 22, pp. 2144-2151. doi: 10.12659/MSM.896494

Milić S, Mikolašević I, Orlić L, Devčić E, Starčević Čizmarević N, Štimac D, and sur.. The Role of Iron and Iron Overload in Chronic Liver Disease. Medical Science Monitor [Internet]. 2016 June 22 [cited 2024 July 08];22:2144-2151. doi: 10.12659/MSM.896494

S. Milić, et al., "The Role of Iron and Iron Overload in Chronic Liver Disease", Medical Science Monitor, vol. 22, pp. 2144-2151, June 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:825437. [Accessed: 08 July 2024]

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Metadata
Title (english)The Role of Iron and Iron Overload in Chronic Liver Disease
AuthorSandra Milić
AuthorIvana Mikolašević
AuthorLidija Orlić
AuthorEdita Devčić
AuthorNada Starčević-Čizmarević
AuthorDavor Štimac
AuthorMiljenko Kapović
AuthorSmiljana Ristić
MBZ: 142283
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
The liver plays a major role in iron homeostasis; thus, in patients with chronic liver disease, iron regulation may be disturbed. Higher iron levels are present not only in patients with hereditary hemochromatosis, but also in those with alcoholic liver disease, nonalcoholic fatty liver disease, and hepatitis C viral infection. Chronic liver disease decreases the synthetic functions of the liver, including the production of hepcidin, a key protein in iron metabolism. Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-transferrin-bound iron in the bloodstream. Iron combined with reactive oxygen species leads to an increase in hydroxyl radicals, which are responsible for phospholipid peroxidation, oxidation of amino acid side chains, DNA strain breaks, and protein fragmentation. Iron-induced cellular damage may be prevented by regulating the production of hepcidin or by administering hepcidin agonists. Both of these methods have yielded successful results in mouse models.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Science Monitor
Numberingvol. 22, pp. 2144-2151
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.896494
URN:NBNurn:nbn:hr:184:825437
Publication2016-06-22
Document URLhttp://www.medscimonit.com/abstract/index/idArt/896494
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-07-31 10:15:30