prikaz prve stranice dokumenta Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
  Preuzmi
PDF 3.95 MB
Znanstveni rad - Izvorni znanstveni rad
Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
Toxics, 13 (2025), 3; 194. https://doi.org/10.3390/toxics13030194
Jakac, Mateo; Brčić Karačonji, Irena; Jurič, Andreja; Lušić, Dražen; Milinčić, Danijel; Dramićanin, Aleksandra; Pešić, Mirjana; Landeka, Nediljko; Kopjar, Nevenka

Citirajte ovaj rad

Jakac, M., Brčić Karačonji, I., Jurič, A., Lušić, D., Milinčić, D., Dramićanin, A. ... Kopjar, N. (2025). Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro. Toxics, 13. (3). doi: 10.3390/toxics13030194

Jakac, Mateo, et al. "Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro." Toxics, vol. 13, br. 3, 2025. https://doi.org/10.3390/toxics13030194

Jakac, Mateo, Irena Brčić Karačonji, Andreja Jurič, Dražen Lušić, Danijel Milinčić, Aleksandra Dramićanin, Mirjana Pešić, Nediljko Landeka i Nevenka Kopjar. "Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro." Toxics 13, br. 3 (2025). https://doi.org/10.3390/toxics13030194

Jakac, M., et al. (2025) 'Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro', Toxics, 13(3). doi: 10.3390/toxics13030194

Jakac M, Brčić Karačonji I, Jurič A, Lušić D, Milinčić D, Dramićanin A, i sur.. Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro. Toxics [Internet]. 08.03.2025. [pristupljeno 11.03.2025.];13(3). doi: 10.3390/toxics13030194

M. Jakac, et al., "Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro", Toxics, vol. 13, br. 3, Ožujak 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:262706. [Citirano: 11.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:262706
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
AutorMateo Jakac
AutorIrena Brčić Karačonji
AutorAndreja Jurič
AutorDražen Lušić
AutorDanijel Milinčić
AutorAleksandra Dramićanin
AutorMirjana Pešić
AutorNediljko Landeka
AutorNevenka Kopjar
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zdravstvenu ekologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Medicinska biokemija
Sažetak (engleski)
Propolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have a remarkable antioxidant activity. Since phenolics may exert a dual nature (pro-oxidant and antioxidant) the aim of this study was to investigate the safety profile of the ethanolic extract of propolis and the related flavonoid galangin and their ability to protect lymphocytes from irinotecan-induced cyto/genotoxicity in vitro. Isolated human peripheral blood lymphocytes were exposed for 3 h to three concentrations of propolis extract and galangin corresponding to the average daily dose of 0.25 mL of extract [propolis in 70% ethanol (3:7, w/w)], as well as a five- and ten-fold higher concentration. Cyto- and genoprotective effects were tested using a cytokinesis-block micronucleus cytome assay. Treatment with propolis and galangin in the selected concentrations exerted high biocompatibility with lymphocytes and diminished the level of cytogenetic damage caused by irinotecan. Propolis at the same concentration offered a stronger protective effect than single galangin. Also, apoptosis was the prevailing mechanism of cell death in our experimental conditions. These preliminary results speak in favour of future investigations of propolis using other available cytogenetic methods and cell models.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaToxics
Brojčani podacivol. 13, br. 3, 194
e-ISSN2305-6304
DOIhttps://doi.org/10.3390/toxics13030194
URN:NBNurn:nbn:hr:184:262706
Datum objave publikacije2025-03-08
URL dokumentahttps://www.mdpi.com/2305-6304/13/3/194
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-11 07:07:24