prikaz prve stranice dokumenta Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
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Scientific paper - Original scientific paper
Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
Toxics, 13 (2025), 3; 194. https://doi.org/10.3390/toxics13030194
Jakac, Mateo; Brčić Karačonji, Irena; Jurič, Andreja; Lušić, Dražen; Milinčić, Danijel; Dramićanin, Aleksandra; Pešić, Mirjana; Landeka, Nediljko; Kopjar, Nevenka

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Jakac, M., Brčić Karačonji, I., Jurič, A., Lušić, D., Milinčić, D., Dramićanin, A. ... Kopjar, N. (2025). Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro. Toxics, 13. (3). doi: 10.3390/toxics13030194

Jakac, Mateo, et al. "Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro." Toxics, vol. 13, no. 3, 2025. https://doi.org/10.3390/toxics13030194

Jakac, Mateo, Irena Brčić Karačonji, Andreja Jurič, Dražen Lušić, Danijel Milinčić, Aleksandra Dramićanin, Mirjana Pešić, Nediljko Landeka and Nevenka Kopjar. "Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro." Toxics 13, no. 3 (2025). https://doi.org/10.3390/toxics13030194

Jakac, M., et al. (2025) 'Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro', Toxics, 13(3). doi: 10.3390/toxics13030194

Jakac M, Brčić Karačonji I, Jurič A, Lušić D, Milinčić D, Dramićanin A, and sur.. Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro. Toxics [Internet]. 2025 March 08 [cited 2025 March 11];13(3). doi: 10.3390/toxics13030194

M. Jakac, et al., "Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro", Toxics, vol. 13, no. 3, March 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:262706. [Accessed: 11 March 2025]

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Metadata
Title (english)Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
AuthorMateo Jakac
AuthorIrena Brčić Karačonji
AuthorAndreja Jurič
AuthorDražen Lušić
AuthorDanijel Milinčić
AuthorAleksandra Dramićanin
AuthorMirjana Pešić
AuthorNediljko Landeka
AuthorNevenka Kopjar
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Environmental Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (english)
Propolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have a remarkable antioxidant activity. Since phenolics may exert a dual nature (pro-oxidant and antioxidant) the aim of this study was to investigate the safety profile of the ethanolic extract of propolis and the related flavonoid galangin and their ability to protect lymphocytes from irinotecan-induced cyto/genotoxicity in vitro. Isolated human peripheral blood lymphocytes were exposed for 3 h to three concentrations of propolis extract and galangin corresponding to the average daily dose of 0.25 mL of extract [propolis in 70% ethanol (3:7, w/w)], as well as a five- and ten-fold higher concentration. Cyto- and genoprotective effects were tested using a cytokinesis-block micronucleus cytome assay. Treatment with propolis and galangin in the selected concentrations exerted high biocompatibility with lymphocytes and diminished the level of cytogenetic damage caused by irinotecan. Propolis at the same concentration offered a stronger protective effect than single galangin. Also, apoptosis was the prevailing mechanism of cell death in our experimental conditions. These preliminary results speak in favour of future investigations of propolis using other available cytogenetic methods and cell models.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleToxics
Numberingvol. 13, no. 3, 194
e-ISSN2305-6304
DOIhttps://doi.org/10.3390/toxics13030194
URN:NBNurn:nbn:hr:184:262706
Publication2025-03-08
Document URLhttps://www.mdpi.com/2305-6304/13/3/194
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-11 07:07:24