prikaz prve stranice dokumenta Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo
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Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo
Journal of general virology, 77 (1996), ( Pt 2 ); 217-225. urn:nbn:hr:184:037338
Polić, Bojan; Jonjić, Stipan; Pavić, Ivica; Crnković, Irena; Zorica, Irena; Hengel, Hartmut; Lučin, Pero; Koszinowski, Ulrich H.

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Polić, B., Jonjić, S., Pavić, I., Crnković, I., Zorica, I., Hengel, H. ... Koszinowski, U. H. (1996). Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo. Journal of general virology, 77. (( Pt 2 )), 217-225. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:037338

Polić, Bojan, et al. "Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo." Journal of general virology, vol. 77, br. ( Pt 2 ), 1996, str. 217-225. https://urn.nsk.hr/urn:nbn:hr:184:037338

Polić, Bojan, Stipan Jonjić, Ivica Pavić, Irena Crnković, Irena Zorica, Hartmut Hengel, Pero Lučin i Ulrich H. Koszinowski. "Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo." Journal of general virology 77, br. ( Pt 2 ) (1996): 217-225. https://urn.nsk.hr/urn:nbn:hr:184:037338

Polić, B., et al. (1996) 'Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo', Journal of general virology, 77(( Pt 2 )), str. 217-225. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:037338 (Datum pristupa: 19.11.2024.)

Polić B, Jonjić S, Pavić I, Crnković I, Zorica I, Hengel H, i sur.. Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo. Journal of general virology [Internet]. 1996. [pristupljeno 19.11.2024.];77(( Pt 2 )):217-225. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:037338

B. Polić, et al., "Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo", Journal of general virology, vol. 77, br. ( Pt 2 ), str. 217-225, 1996. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:037338. [Citirano: 19.11.2024.]

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Naslov (engleski)Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo
AutorBojan Polić
AutorStipan Jonjić
AutorIvica Pavić
AutorIrena Crnković
AutorIrena Zorica
AutorHartmut Hengel
AutorPero Lučin
AutorUlrich H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
It has been claimed that MHC class I proteins serve as receptors for murine cytomegalovirus (MCMV) and that this interaction is the most important mechanism for virus entry in most cells. This claim is based on the observation that the MHC haplotype contributes to the susceptibility to cytomegalovirus (CMV) infection in vivo. Results from in vitro studies support the concept that stable expression of correctly folded MHC class I molecules contributes to infection, since the individual properties of MHC class I alleles, the availability of beta 2-microglobulin (beta 2m) and also the degree of peptide charging of the MHC class I heavy chain beta 2m heterodimers determined the infection phenotype of cell lines. To assess the biological relevance of proper MHC class I expression we investigated CMV infection in beta 2m-deficient mice which fail to express ternary MHC class I complexes and lack peripheral CD8+ T lymphocytes. We found that organ virus titres and virus clearance kinetics were not altered in beta 2m mutant mice. In addition, there was no indication of diminished virus propagation in beta 2m-/- embryonic fibroblasts. beta 2m-/- mice suffered from the lack of CD8+ T lymphocytes that was partially compensated for by the function of CD4+ T lymphocytes. An organ-specific anti-virus function of natural killer (NK) cells was observed, independent from the beta 2m deletion. The immune control unique for salivary gland infection was maintained. From the data presented here, we confirm the role of MHC class I molecules in the immune surveillance of CMV infection but question the biological impact of correct MHC class I complexes for productive infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of general virology
Brojčani podacivol. 77, br. ( Pt 2 ), str. 217-225
p-ISSN0022-1317
URN:NBNurn:nbn:hr:184:037338
Datum objave publikacije1996
URL dokumentahttp://bib.irb.hr/101576
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-20 14:16:20