prikaz prve stranice dokumenta Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo
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Scientific paper - Original scientific paper
Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo
Journal of general virology, 77 (1996), ( Pt 2 ); 217-225. urn:nbn:hr:184:037338
Polić, Bojan; Jonjić, Stipan; Pavić, Ivica; Crnković, Irena; Zorica, Irena; Hengel, Hartmut; Lučin, Pero; Koszinowski, Ulrich H.

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Polić, B., Jonjić, S., Pavić, I., Crnković, I., Zorica, I., Hengel, H. ... Koszinowski, U. H. (1996). Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo. Journal of general virology, 77. (( Pt 2 )), 217-225. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:037338

Polić, Bojan, et al. "Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo." Journal of general virology, vol. 77, no. ( Pt 2 ), 1996, pp. 217-225. https://urn.nsk.hr/urn:nbn:hr:184:037338

Polić, Bojan, Stipan Jonjić, Ivica Pavić, Irena Crnković, Irena Zorica, Hartmut Hengel, Pero Lučin and Ulrich H. Koszinowski. "Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo." Journal of general virology 77, no. ( Pt 2 ) (1996): 217-225. https://urn.nsk.hr/urn:nbn:hr:184:037338

Polić, B., et al. (1996) 'Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo', Journal of general virology, 77(( Pt 2 )), pp. 217-225. Available at: https://urn.nsk.hr/urn:nbn:hr:184:037338 (Accessed 13 November 2024)

Polić B, Jonjić S, Pavić I, Crnković I, Zorica I, Hengel H, and sur.. Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo. Journal of general virology [Internet]. 1996 [cited 2024 November 13];77(( Pt 2 )):217-225. Available at: https://urn.nsk.hr/urn:nbn:hr:184:037338

B. Polić, et al., "Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo", Journal of general virology, vol. 77, no. ( Pt 2 ), pp. 217-225, 1996. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:037338. [Accessed: 13 November 2024]

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Metadata
Title (english)Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo
AuthorBojan Polić
AuthorStipan Jonjić
AuthorIvica Pavić
AuthorIrena Crnković
AuthorIrena Zorica
AuthorHartmut Hengel
AuthorPero Lučin
AuthorUlrich H. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
It has been claimed that MHC class I proteins serve as receptors for murine cytomegalovirus (MCMV) and that this interaction is the most important mechanism for virus entry in most cells. This claim is based on the observation that the MHC haplotype contributes to the susceptibility to cytomegalovirus (CMV) infection in vivo. Results from in vitro studies support the concept that stable expression of correctly folded MHC class I molecules contributes to infection, since the individual properties of MHC class I alleles, the availability of beta 2-microglobulin (beta 2m) and also the degree of peptide charging of the MHC class I heavy chain beta 2m heterodimers determined the infection phenotype of cell lines. To assess the biological relevance of proper MHC class I expression we investigated CMV infection in beta 2m-deficient mice which fail to express ternary MHC class I complexes and lack peripheral CD8+ T lymphocytes. We found that organ virus titres and virus clearance kinetics were not altered in beta 2m mutant mice. In addition, there was no indication of diminished virus propagation in beta 2m-/- embryonic fibroblasts. beta 2m-/- mice suffered from the lack of CD8+ T lymphocytes that was partially compensated for by the function of CD4+ T lymphocytes. An organ-specific anti-virus function of natural killer (NK) cells was observed, independent from the beta 2m deletion. The immune control unique for salivary gland infection was maintained. From the data presented here, we confirm the role of MHC class I molecules in the immune surveillance of CMV infection but question the biological impact of correct MHC class I complexes for productive infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of general virology
Numberingvol. 77, no. ( Pt 2 ), pp. 217-225
p-ISSN0022-1317
URN:NBNurn:nbn:hr:184:037338
Publication1996
Document URLhttp://bib.irb.hr/101576
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-20 14:16:20