prikaz prve stranice dokumenta Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study
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Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study
Collegium antropologicum, 34 supplement 2 (2010), 2; 119-125. urn:nbn:hr:184:214122
Španjol, Josip; Djordjević, Gordana; Markić, Dean; Klarić, Marko; Fučkar, Dora; Bobinac, Dragica

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Španjol, J., Djordjević, G., Markić, D., Klarić, M., Fučkar, D. i Bobinac, D. (2010). Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study. Collegium antropologicum, 34 supplement 2. (2), 119-125. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:214122

Španjol, Josip, et al. "Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study." Collegium antropologicum, vol. 34 supplement 2, br. 2, 2010, str. 119-125. https://urn.nsk.hr/urn:nbn:hr:184:214122

Španjol, Josip, Gordana Djordjević, Dean Markić, Marko Klarić, Dora Fučkar i Dragica Bobinac. "Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study." Collegium antropologicum 34 supplement 2, br. 2 (2010): 119-125. https://urn.nsk.hr/urn:nbn:hr:184:214122

Španjol, J., et al. (2010) 'Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study', Collegium antropologicum, 34 supplement 2(2), str. 119-125. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:214122 (Datum pristupa: 27.12.2024.)

Španjol J, Djordjević G, Markić D, Klarić M, Fučkar D, Bobinac D. Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study. Collegium antropologicum [Internet]. 2010. [pristupljeno 27.12.2024.];34 supplement 2(2):119-125. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:214122

J. Španjol, G. Djordjević, D. Markić, M. Klarić, D. Fučkar i D. Bobinac, "Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study", Collegium antropologicum, vol. 34 supplement 2, br. 2, str. 119-125, 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:214122. [Citirano: 27.12.2024.]

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Naslov (engleski)Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study
AutorJosip Španjol
AutorGordana Djordjević
AutorDean Markić
AutorMarko Klarić
AutorDora Fučkar
AutorDragica Bobinac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
Bone morphogenetic proteins (BMP) have the ability to induce ectopic bone formation1–10. The findings of their expression in prostate cancers have been linked with specifically tumor progression to bone and development of osteosclerotic metastases7–15. We investigated the expression pattern of BMP-2/4, -6 and -7 and the receptors BMPR-IA,-IB and -II in normal human prostate, organ-localized and metastatic prostate cancers. The expression we also examined in skeletal metastases caused by prostate cancer. In localized prostate cancers we found increased expression of BMP-6 and decreased expression of BMP-2/4 and -7. In metastatic prostate cancers the expression of examined BMPs decreased. The expression of BMPRs showed the tendency to be lower with progression of prostate cancer but the expression of BMPR-II was completely absent in metastatic prostate cancers. In bone metastases caused by prostate cancer we found high expression of BMP-2/4, -6 and -7. Decreased expression of BMPs and lose of BMPR-II expression, could suggest that the influence of BMPs on prostate cancer cells is inhibited and plays an important role in prostate cancer pathogenesis. High expression of osteogenic BMPs in prostate cancer bone metastases could explain their osteosclerotic properties.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 34 supplement 2, br. 2, str. 119-125
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:214122
Datum objave publikacije2010
URL dokumentahttps://hrcak.srce.hr/51642
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-01 14:56:33