prikaz prve stranice dokumenta Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study
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Scientific paper - Original scientific paper
Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study
Collegium antropologicum, 34 supplement 2 (2010), 2; 119-125. urn:nbn:hr:184:214122
Španjol, Josip; Djordjević, Gordana; Markić, Dean; Klarić, Marko; Fučkar, Dora; Bobinac, Dragica

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Španjol, J., Djordjević, G., Markić, D., Klarić, M., Fučkar, D. & Bobinac, D. (2010). Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study. Collegium antropologicum, 34 supplement 2. (2), 119-125. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:214122

Španjol, Josip, et al. "Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study." Collegium antropologicum, vol. 34 supplement 2, no. 2, 2010, pp. 119-125. https://urn.nsk.hr/urn:nbn:hr:184:214122

Španjol, Josip, Gordana Djordjević, Dean Markić, Marko Klarić, Dora Fučkar and Dragica Bobinac. "Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study." Collegium antropologicum 34 supplement 2, no. 2 (2010): 119-125. https://urn.nsk.hr/urn:nbn:hr:184:214122

Španjol, J., et al. (2010) 'Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study', Collegium antropologicum, 34 supplement 2(2), pp. 119-125. Available at: https://urn.nsk.hr/urn:nbn:hr:184:214122 (Accessed 23 January 2025)

Španjol J, Djordjević G, Markić D, Klarić M, Fučkar D, Bobinac D. Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study. Collegium antropologicum [Internet]. 2010 [cited 2025 January 23];34 supplement 2(2):119-125. Available at: https://urn.nsk.hr/urn:nbn:hr:184:214122

J. Španjol, G. Djordjević, D. Markić, M. Klarić, D. Fučkar and D. Bobinac, "Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study", Collegium antropologicum, vol. 34 supplement 2, no. 2, pp. 119-125, 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:214122. [Accessed: 23 January 2025]

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Title (english)Role of Bone Morphogenetic Proteins in Human Prostate Cancer Pathogenesis and Development of Bone Metastases: Immunohistochemical Study
AuthorJosip Španjol
AuthorGordana Djordjević
AuthorDean Markić
AuthorMarko Klarić
AuthorDora Fučkar
AuthorDragica Bobinac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Bone morphogenetic proteins (BMP) have the ability to induce ectopic bone formation1–10. The findings of their expression in prostate cancers have been linked with specifically tumor progression to bone and development of osteosclerotic metastases7–15. We investigated the expression pattern of BMP-2/4, -6 and -7 and the receptors BMPR-IA,-IB and -II in normal human prostate, organ-localized and metastatic prostate cancers. The expression we also examined in skeletal metastases caused by prostate cancer. In localized prostate cancers we found increased expression of BMP-6 and decreased expression of BMP-2/4 and -7. In metastatic prostate cancers the expression of examined BMPs decreased. The expression of BMPRs showed the tendency to be lower with progression of prostate cancer but the expression of BMPR-II was completely absent in metastatic prostate cancers. In bone metastases caused by prostate cancer we found high expression of BMP-2/4, -6 and -7. Decreased expression of BMPs and lose of BMPR-II expression, could suggest that the influence of BMPs on prostate cancer cells is inhibited and plays an important role in prostate cancer pathogenesis. High expression of osteogenic BMPs in prostate cancer bone metastases could explain their osteosclerotic properties.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 34 supplement 2, no. 2, pp. 119-125
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:214122
Publication2010
Document URLhttps://hrcak.srce.hr/51642
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-01 14:56:33