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NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo
Journal of immunology, 196 (2016), 11; 4805-4813. https://doi.org/10.4049/jimmunol.1501982
Raju, Saravanan; ...; Polić, Bojan; ...

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Raju, S. i Polić, B. (2016). NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo. Journal of immunology, 196. (11), 4805-4813. doi: 10.4049/jimmunol.1501982

Raju, Saravanan i Bojan Polić. "NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo." Journal of immunology, vol. 196, br. 11, 2016, str. 4805-4813. https://doi.org/10.4049/jimmunol.1501982

Raju, Saravanan i Bojan Polić. "NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo." Journal of immunology 196, br. 11 (2016): 4805-4813. https://doi.org/10.4049/jimmunol.1501982

Raju, S. i Polić, B. (2016) 'NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo', Journal of immunology, 196(11), str. 4805-4813. doi: 10.4049/jimmunol.1501982

Raju S, Polić B. NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo. Journal of immunology [Internet]. 2016. [pristupljeno 13.11.2024.];196(11):4805-4813. doi: 10.4049/jimmunol.1501982

S. Raju i B. Polić, "NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo", Journal of immunology, vol. 196, br. 11, str. 4805-4813, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:143473. [Citirano: 13.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:143473
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Naslov (engleski)NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo
AutorSaravanan Raju
Autor
...
AutorBojan Polić
Autor
...
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
It is now clear that recognition of nascent tumors by the immune system is critical for survival of the host against cancer. During cancer immunoediting, the ability of the tumor to escape immune recognition is important for tumor development. The immune system recognizes tumors via the presence of classical Ags and also by conserved innate mechanisms. One of these mechanisms is the NKG2D receptor that recognizes ligands whose expression is induced by cell transformation. In this study, we show that in NKG2D receptor–deficient mice, increasing numbers of B cells begin to express NKG2D ligands as they age. Their absence in wild-type mice suggests that these cells are normally cleared by NKG2D-expressing cells. NKG2D-deficient mice and mice constitutively expressing NKG2D ligands had increased incidence of B cell tumors, confirming that the inability to clear NKG2D ligand–expressing cells was important in tumor suppression and that NKG2D ligand expression is a marker of nascent tumors. Supporting a role for NKG2D ligand expression in controlling the progression of early-stage B cell lymphomas in humans, we found higher expression of a microRNA that inhibits human NKG2D ligand expression in tumor cells from high-grade compared with low-grade follicular lymphoma patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of immunology
Brojčani podacivol. 196, br. 11, str. 4805-4813
p-ISSN0022-1767
DOIhttps://doi.org/10.4049/jimmunol.1501982
URN:NBNurn:nbn:hr:184:143473
Datum objave publikacije2016
ProjektŠifra: 062-0621261-1271
Naziv (hrvatski): Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava
Naziv (engleski): The role of NKG2D in the development and effector functions of the immune system
Voditelj: Bojan Polić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/821058
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-28 14:30:28