prikaz prve stranice dokumenta NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo
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Scientific paper - Original scientific paper
NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo
Journal of immunology, 196 (2016), 11; 4805-4813. https://doi.org/10.4049/jimmunol.1501982
Raju, Saravanan; ...; Polić, Bojan; ...

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Raju, S. & Polić, B. (2016). NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo. Journal of immunology, 196. (11), 4805-4813. doi: 10.4049/jimmunol.1501982

Raju, Saravanan and Bojan Polić. "NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo." Journal of immunology, vol. 196, no. 11, 2016, pp. 4805-4813. https://doi.org/10.4049/jimmunol.1501982

Raju, Saravanan and Bojan Polić. "NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo." Journal of immunology 196, no. 11 (2016): 4805-4813. https://doi.org/10.4049/jimmunol.1501982

Raju, S. and Polić, B. (2016) 'NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo', Journal of immunology, 196(11), pp. 4805-4813. doi: 10.4049/jimmunol.1501982

Raju S, Polić B. NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo. Journal of immunology [Internet]. 2016 [cited 2024 November 28];196(11):4805-4813. doi: 10.4049/jimmunol.1501982

S. Raju and B. Polić, "NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo", Journal of immunology, vol. 196, no. 11, pp. 4805-4813, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:143473. [Accessed: 28 November 2024]

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Metadata
Title (english)NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo
AuthorSaravanan Raju
Author
...
AuthorBojan Polić
Author
...
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
It is now clear that recognition of nascent tumors by the immune system is critical for survival of the host against cancer. During cancer immunoediting, the ability of the tumor to escape immune recognition is important for tumor development. The immune system recognizes tumors via the presence of classical Ags and also by conserved innate mechanisms. One of these mechanisms is the NKG2D receptor that recognizes ligands whose expression is induced by cell transformation. In this study, we show that in NKG2D receptor–deficient mice, increasing numbers of B cells begin to express NKG2D ligands as they age. Their absence in wild-type mice suggests that these cells are normally cleared by NKG2D-expressing cells. NKG2D-deficient mice and mice constitutively expressing NKG2D ligands had increased incidence of B cell tumors, confirming that the inability to clear NKG2D ligand–expressing cells was important in tumor suppression and that NKG2D ligand expression is a marker of nascent tumors. Supporting a role for NKG2D ligand expression in controlling the progression of early-stage B cell lymphomas in humans, we found higher expression of a microRNA that inhibits human NKG2D ligand expression in tumor cells from high-grade compared with low-grade follicular lymphoma patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of immunology
Numberingvol. 196, no. 11, pp. 4805-4813
p-ISSN0022-1767
DOIhttps://doi.org/10.4049/jimmunol.1501982
URN:NBNurn:nbn:hr:184:143473
Publication2016
ProjectNumber: 062-0621261-1271
Title (croatian): Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava
Title (english): The role of NKG2D in the development and effector functions of the immune system
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/821058
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-28 14:30:28