prikaz prve stranice dokumenta CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice
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CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice
Medical microbiology and immunology, 208 (2019), 3-4; 487-494. https://doi.org/10.1007/s00430-019-00601-0
Brizić, Ilija; Hiršl, Lea; Šustić, Marko; Golemac, Mijo; Britt, William J.; Krmpotić, Astrid; Jonjić, Stipan

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Brizić, I., Hiršl, L., Šustić, M., Golemac, M., Britt, W. J., Krmpotić, A. i Jonjić, S. (2019). CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice. Medical microbiology and immunology, 208. (3-4), 487-494. doi: 10.1007/s00430-019-00601-0

Brizić, Ilija, et al. "CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice." Medical microbiology and immunology, vol. 208, br. 3-4, 2019, str. 487-494. https://doi.org/10.1007/s00430-019-00601-0

Brizić, Ilija, Lea Hiršl, Marko Šustić, Mijo Golemac, William J. Britt, Astrid Krmpotić i Stipan Jonjić. "CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice." Medical microbiology and immunology 208, br. 3-4 (2019): 487-494. https://doi.org/10.1007/s00430-019-00601-0

Brizić, I., et al. (2019) 'CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice', Medical microbiology and immunology, 208(3-4), str. 487-494. doi: 10.1007/s00430-019-00601-0

Brizić I, Hiršl L, Šustić M, Golemac M, Britt WJ, Krmpotić A, i sur.. CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice. Medical microbiology and immunology [Internet]. 2019. [pristupljeno 05.05.2024.];208(3-4):487-494. doi: 10.1007/s00430-019-00601-0

I. Brizić, et al., "CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice", Medical microbiology and immunology, vol. 208, br. 3-4, str. 487-494, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:037743. [Citirano: 05.05.2024.]

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Naslov (engleski)CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice
AutorIlija Brizić
AutorLea Hiršl https://orcid.org/0000-0003-1431-8581
AutorMarko Šustić https://orcid.org/0000-0001-8213-0578
AutorMijo Golemac
AutorWilliam J. Britt
AutorAstrid Krmpotić
AutorStipan Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
Cytomegalovirus (CMV) infection is a significant public health problem. Congenital CMV infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and sensorineural hearing loss. Immune protection against mouse cytomegalovirus (MCMV) is primarily mediated by NK cells and CD8+ T cells, while CD4+ T cells are not needed for control of MCMV in majority of organs in immunocompetent adult mice. Here, we set out to determine the role of CD4+ T cells upon MCMV infection of newborn mice. We provide evidence that CD4+ T cells are essential for clearance of MCMV infection in brain of neonatal mice and for prevention of recurrence of latent MCMV. In addition, we provide evidence that CD4+ T cells are required for induction and maintenance of tissue- resident memory CD8+ T cells in the brain of mice perinatally infected with MCMV.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical microbiology and immunology
Brojčani podacivol. 208, br. 3-4, str. 487-494
p-ISSN0300-8584
DOIhttps://doi.org/10.1007/s00430-019-00601-0
URN:NBNurn:nbn:hr:184:037743
Datum objave publikacije2019
ProjektŠifra: uniri-biomed-18-297
Naziv (hrvatski): Uloga tkivno-rezidentnih CD4+ limfocita T u mozgu kongenitalno inficiranih miševa
Naziv (engleski): The role of brain-resident CD4+ T cells in congenitally infected mice
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: KK.011.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: ERDF
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttp://bib.irb.hr/1034903
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2022-02-09 16:43:56