prikaz prve stranice dokumenta CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice
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Scientific paper - Original scientific paper
CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice
Medical microbiology and immunology, 208 (2019), 3-4; 487-494. https://doi.org/10.1007/s00430-019-00601-0
Brizić, Ilija; Hiršl, Lea; Šustić, Marko; Golemac, Mijo; Britt, William J.; Krmpotić, Astrid; Jonjić, Stipan

Cite this document

Brizić, I., Hiršl, L., Šustić, M., Golemac, M., Britt, W. J., Krmpotić, A. & Jonjić, S. (2019). CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice. Medical microbiology and immunology, 208. (3-4), 487-494. doi: 10.1007/s00430-019-00601-0

Brizić, Ilija, et al. "CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice." Medical microbiology and immunology, vol. 208, no. 3-4, 2019, pp. 487-494. https://doi.org/10.1007/s00430-019-00601-0

Brizić, Ilija, Lea Hiršl, Marko Šustić, Mijo Golemac, William J. Britt, Astrid Krmpotić and Stipan Jonjić. "CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice." Medical microbiology and immunology 208, no. 3-4 (2019): 487-494. https://doi.org/10.1007/s00430-019-00601-0

Brizić, I., et al. (2019) 'CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice', Medical microbiology and immunology, 208(3-4), pp. 487-494. doi: 10.1007/s00430-019-00601-0

Brizić I, Hiršl L, Šustić M, Golemac M, Britt WJ, Krmpotić A, and sur.. CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice. Medical microbiology and immunology [Internet]. 2019 [cited 2024 December 23];208(3-4):487-494. doi: 10.1007/s00430-019-00601-0

I. Brizić, et al., "CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice", Medical microbiology and immunology, vol. 208, no. 3-4, pp. 487-494, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:037743. [Accessed: 23 December 2024]

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Metadata
Title (english)CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice
AuthorIlija Brizić
AuthorLea Hiršl https://orcid.org/0000-0003-1431-8581
AuthorMarko Šustić https://orcid.org/0000-0001-8213-0578
AuthorMijo Golemac
AuthorWilliam J. Britt
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
Cytomegalovirus (CMV) infection is a significant public health problem. Congenital CMV infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and sensorineural hearing loss. Immune protection against mouse cytomegalovirus (MCMV) is primarily mediated by NK cells and CD8+ T cells, while CD4+ T cells are not needed for control of MCMV in majority of organs in immunocompetent adult mice. Here, we set out to determine the role of CD4+ T cells upon MCMV infection of newborn mice. We provide evidence that CD4+ T cells are essential for clearance of MCMV infection in brain of neonatal mice and for prevention of recurrence of latent MCMV. In addition, we provide evidence that CD4+ T cells are required for induction and maintenance of tissue- resident memory CD8+ T cells in the brain of mice perinatally infected with MCMV.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical microbiology and immunology
Numberingvol. 208, no. 3-4, pp. 487-494
p-ISSN0300-8584
DOIhttps://doi.org/10.1007/s00430-019-00601-0
URN:NBNurn:nbn:hr:184:037743
Publication2019
ProjectNumber: uniri-biomed-18-297
Title (croatian): Uloga tkivno-rezidentnih CD4+ limfocita T u mozgu kongenitalno inficiranih miševa
Title (english): The role of brain-resident CD4+ T cells in congenitally infected mice
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: Croatia
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttp://bib.irb.hr/1034903
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-09 16:43:56