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Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study
Acta clinica Croatica, 60. (2021), Supplement 1; 71-77. https://doi.org/10.20471/acc.2021.60.s1.11
Laganović, Mario; Horvatić, Ivica; Bubić, Ivan; Ilić, Mario; Maksimović, Bojana; Kozmar, Ana; Vuković Brinar, Ivana; Crnogorac, Matija; Živko, Marijana; Fištrek, Margareta; Jureković, Željka; Galešić Ljubanović, Danica; Ćorić, Marijana; Bulimbašić, Stela; Galešić, Krešimir; Knotek, Mladen Više autora...

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Laganović, M., Horvatić, I., Bubić, I., Ilić, M., Maksimović, B., Kozmar, A. ... Knotek, M. (2021). Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study. Acta clinica Croatica, 60.. (Supplement 1), 71-77. doi: 10.20471/acc.2021.60.s1.11

Laganović, Mario, et al. "Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study." Acta clinica Croatica, vol. 60., br. Supplement 1, 2021, str. 71-77. https://doi.org/10.20471/acc.2021.60.s1.11

Laganović, Mario, Ivica Horvatić, Ivan Bubić, Mario Ilić, Bojana Maksimović, Ana Kozmar, Ivana Vuković Brinar, et al. "Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study." Acta clinica Croatica 60., br. Supplement 1 (2021): 71-77. https://doi.org/10.20471/acc.2021.60.s1.11

Laganović, M., et al. (2021) 'Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study', Acta clinica Croatica, 60.(Supplement 1), str. 71-77. doi: 10.20471/acc.2021.60.s1.11

Laganović M, Horvatić I, Bubić I, Ilić M, Maksimović B, Kozmar A, i sur.. Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study. Acta clinica Croatica [Internet]. 2021. [pristupljeno 26.12.2024.];60.(Supplement 1):71-77. doi: 10.20471/acc.2021.60.s1.11

M. Laganović, et al., "Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study", Acta clinica Croatica, vol. 60., br. Supplement 1, str. 71-77, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:204768. [Citirano: 26.12.2024.]

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Naslov (engleski)Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study
Naslov (hrvatski)Povezanost protutijela na receptor za M-tip fosfolipazu A2 s kliničkim karakteristikama i ishodom bolesnika s primarnom membranskom nefropatijom u 5-godišnjem praćenju
AutorMario Laganović https://orcid.org/0000-0002-0240-4178
AutorIvica Horvatić
AutorIvan Bubić
AutorMario Ilić
AutorBojana Maksimović
AutorAna Kozmar
AutorIvana Vuković Brinar
AutorMatija Crnogorac
AutorMarijana Živko
AutorMargareta Fištrek
AutorŽeljka Jureković
AutorDanica Galešić Ljubanović
AutorMarijana Ćorić
AutorStela Bulimbašić
AutorKrešimir Galešić
AutorMladen Knotek
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB status. Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were included in the study. PLA2R-AB (ELI SA method) and outcomes (defined according to KDIGO) were evaluated after 21 and 64 months of follow-up in 28 patients. Results: 19 patients had positive PLA2R-AB (>20 RU /ml) (59.3%), with median titer of 97 (21-1418 RU /ml). The rate of remission in low PLA2R-AB titer group (< 200 RU /ml) after 21 months was significantly higher than in high PLA2R-AB group (> 200 RU /ml) (90% vs. 50%, p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse rate after 64 months was higher in the high PLA2R-AB group (87% vs. 63%). Multivariant linear regression found serum creatinine (ß=0.682, p<0.001) and PLA2R-AB (ß=0.527, p<0.001) as significant predictors for kidney function at the end of follow-up. Conclusion: higher titers of PLA2R-AB are related to worse kidney function outcome, higher 24-hour proteinuria, and a higher number of relapses in patients with pMN.
Sažetak (hrvatski)
Uvod: primarna membranska nefropatija (pMN) je glomerulopatija, koja je u većini slučajeva uzrokovana autoprotutijelima na receptor za fosfolipazu A2 (PLA2R-PT). Cilj ovog istraživanja bio je analizirati povezanost PLA2R-PT s kliničkim tijekom i ishodima bolesti. Ispitanici i metode: 32 bolesnika (21 muškaraca, 11 žena), s biopsijom bubrega dijagnosticiranim pMN, bilo je uključeno u istraživanje. PLA2R-PT (ELI SA metoda) i ishodi (definirani u skladu s KDIGO) određeni su nakon 21 i 64 mjeseca praćenja u 28 bolesnika. Rezultati: 19 bolesnika imalo je pozitivna PLA2R-PT (>20 RU /ml) (59.3%), s medijanom titra 97 (21-1418 RU /ml). Stopa remisije u skupini s niskim titrom PLA2R-PT (< 200 RU /ml) nakon 21 mjeseca bila je značajno viša u odnosu na skupinu s visokim titrom PLA2R-PT (> 200 RU /ml) (90% vs. 50%, p=0.045), a nakon 64 mjeseca razlika nije bila značajna (80% vs 50%, p=0.210). Stopa relapsa nakon 64 mjeseca bila je viša u skupini s visokim titrom PLA2R-PT (87% vs. 63%). Multivarijatnom linearnom regresijom su kao značajni neovisni prediktori za bubrežnu funkciju na kraju praćenja nađeni serumski kreatinin (ß=0.682, p<0.001) i PLA2R-PT (ß=0.527, p<0.001). Zaključak: viši titar PLA2R-PT povezan je s lošijim ishodom bubrežne funkcije, višom 24-satnom proteinurijom i većom stopom relapsa u bolesnika s pMN.
Ključne riječi (engleski)
Ključne riječi (hrvatski)
Jezikengleski
Jezikhrvatski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa clinica Croatica
Brojčani podacivol. 60., br. Supplement 1, str. 71-77
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2021.60.s1.11
URN:NBNurn:nbn:hr:184:204768
Datum objave publikacije2021
URL dokumentahttps://hrcak.srce.hr/260405
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-08-31 10:11:41