prikaz prve stranice dokumenta Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study
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Scientific paper - Original scientific paper
Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study
Acta clinica Croatica, 60. (2021), Supplement 1; 71-77. https://doi.org/10.20471/acc.2021.60.s1.11
Laganović, Mario; Horvatić, Ivica; Bubić, Ivan; Ilić, Mario; Maksimović, Bojana; Kozmar, Ana; Vuković Brinar, Ivana; Crnogorac, Matija; Živko, Marijana; Fištrek, Margareta; Jureković, Željka; Galešić Ljubanović, Danica; Ćorić, Marijana; Bulimbašić, Stela; Galešić, Krešimir; Knotek, Mladen More authors...

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Laganović, M., Horvatić, I., Bubić, I., Ilić, M., Maksimović, B., Kozmar, A. ... Knotek, M. (2021). Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study. Acta clinica Croatica, 60.. (Supplement 1), 71-77. doi: 10.20471/acc.2021.60.s1.11

Laganović, Mario, et al. "Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study." Acta clinica Croatica, vol. 60., no. Supplement 1, 2021, pp. 71-77. https://doi.org/10.20471/acc.2021.60.s1.11

Laganović, Mario, Ivica Horvatić, Ivan Bubić, Mario Ilić, Bojana Maksimović, Ana Kozmar, Ivana Vuković Brinar, et al. "Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study." Acta clinica Croatica 60., no. Supplement 1 (2021): 71-77. https://doi.org/10.20471/acc.2021.60.s1.11

Laganović, M., et al. (2021) 'Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study', Acta clinica Croatica, 60.(Supplement 1), pp. 71-77. doi: 10.20471/acc.2021.60.s1.11

Laganović M, Horvatić I, Bubić I, Ilić M, Maksimović B, Kozmar A, and sur.. Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study. Acta clinica Croatica [Internet]. 2021 [cited 2024 July 18];60.(Supplement 1):71-77. doi: 10.20471/acc.2021.60.s1.11

M. Laganović, et al., "Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study", Acta clinica Croatica, vol. 60., no. Supplement 1, pp. 71-77, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:204768. [Accessed: 18 July 2024]

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Title (english)Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study
Title (croatian)Povezanost protutijela na receptor za M-tip fosfolipazu A2 s kliničkim karakteristikama i ishodom bolesnika s primarnom membranskom nefropatijom u 5-godišnjem praćenju
AuthorMario Laganović https://orcid.org/0000-0002-0240-4178
AuthorIvica Horvatić
AuthorIvan Bubić
AuthorMario Ilić
AuthorBojana Maksimović
AuthorAna Kozmar
AuthorIvana Vuković Brinar
AuthorMatija Crnogorac
AuthorMarijana Živko
AuthorMargareta Fištrek
AuthorŽeljka Jureković
AuthorDanica Galešić Ljubanović
AuthorMarijana Ćorić
AuthorStela Bulimbašić
AuthorKrešimir Galešić
AuthorMladen Knotek
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB status. Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were included in the study. PLA2R-AB (ELI SA method) and outcomes (defined according to KDIGO) were evaluated after 21 and 64 months of follow-up in 28 patients. Results: 19 patients had positive PLA2R-AB (>20 RU /ml) (59.3%), with median titer of 97 (21-1418 RU /ml). The rate of remission in low PLA2R-AB titer group (< 200 RU /ml) after 21 months was significantly higher than in high PLA2R-AB group (> 200 RU /ml) (90% vs. 50%, p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse rate after 64 months was higher in the high PLA2R-AB group (87% vs. 63%). Multivariant linear regression found serum creatinine (ß=0.682, p<0.001) and PLA2R-AB (ß=0.527, p<0.001) as significant predictors for kidney function at the end of follow-up. Conclusion: higher titers of PLA2R-AB are related to worse kidney function outcome, higher 24-hour proteinuria, and a higher number of relapses in patients with pMN.
Abstract (croatian)
Uvod: primarna membranska nefropatija (pMN) je glomerulopatija, koja je u većini slučajeva uzrokovana autoprotutijelima na receptor za fosfolipazu A2 (PLA2R-PT). Cilj ovog istraživanja bio je analizirati povezanost PLA2R-PT s kliničkim tijekom i ishodima bolesti. Ispitanici i metode: 32 bolesnika (21 muškaraca, 11 žena), s biopsijom bubrega dijagnosticiranim pMN, bilo je uključeno u istraživanje. PLA2R-PT (ELI SA metoda) i ishodi (definirani u skladu s KDIGO) određeni su nakon 21 i 64 mjeseca praćenja u 28 bolesnika. Rezultati: 19 bolesnika imalo je pozitivna PLA2R-PT (>20 RU /ml) (59.3%), s medijanom titra 97 (21-1418 RU /ml). Stopa remisije u skupini s niskim titrom PLA2R-PT (< 200 RU /ml) nakon 21 mjeseca bila je značajno viša u odnosu na skupinu s visokim titrom PLA2R-PT (> 200 RU /ml) (90% vs. 50%, p=0.045), a nakon 64 mjeseca razlika nije bila značajna (80% vs 50%, p=0.210). Stopa relapsa nakon 64 mjeseca bila je viša u skupini s visokim titrom PLA2R-PT (87% vs. 63%). Multivarijatnom linearnom regresijom su kao značajni neovisni prediktori za bubrežnu funkciju na kraju praćenja nađeni serumski kreatinin (ß=0.682, p<0.001) i PLA2R-PT (ß=0.527, p<0.001). Zaključak: viši titar PLA2R-PT povezan je s lošijim ishodom bubrežne funkcije, višom 24-satnom proteinurijom i većom stopom relapsa u bolesnika s pMN.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 60., no. Supplement 1, pp. 71-77
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2021.60.s1.11
URN:NBNurn:nbn:hr:184:204768
Publication2021
Document URLhttps://hrcak.srce.hr/260405
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2021-08-31 10:11:41