prikaz prve stranice dokumenta Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells
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Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells
Blood, 110 (2007), 9; 3472-3479. https://doi.org/10.1182/blood-2007-06-095414
Klenovsek, K.; Weisel, F.; Schneider, A.; Appelt, U.; Jonjić, Stipan; Messerle, Martin; Bradel-Tretheway, B.; Winkler, T. H.; Mach, M.

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Klenovsek, K., Weisel, F., Schneider, A., Appelt, U., Jonjić, S., Messerle, M. ... Mach, M. (2007). Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood, 110. (9), 3472-3479. doi: 10.1182/blood-2007-06-095414

Klenovsek, K., et al. "Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells." Blood, vol. 110, br. 9, 2007, str. 3472-3479. https://doi.org/10.1182/blood-2007-06-095414

Klenovsek, K., F. Weisel, A. Schneider, U. Appelt, Stipan Jonjić, Martin Messerle, B. Bradel Tretheway, T. H. Winkler i M. Mach. "Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells." Blood 110, br. 9 (2007): 3472-3479. https://doi.org/10.1182/blood-2007-06-095414

Klenovsek, K., et al. (2007) 'Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells', Blood, 110(9), str. 3472-3479. doi: 10.1182/blood-2007-06-095414

Klenovsek K, Weisel F, Schneider A, Appelt U, Jonjić S, Messerle M, i sur.. Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood [Internet]. 01.11.2007. [pristupljeno 11.11.2024.];110(9):3472-3479. doi: 10.1182/blood-2007-06-095414

K. Klenovsek, et al., "Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells", Blood, vol. 110, br. 9, str. 3472-3479, Studeni 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:500526. [Citirano: 11.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:500526
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Naslov (engleski)Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells
AutorK. Klenovsek
AutorF. Weisel
AutorA. Schneider
AutorU. Appelt
AutorStipan Jonjić
AutorMartin Messerle
AutorB. Bradel-Tretheway
AutorT. H. Winkler
AutorM. Mach
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Severe disease associated with cytomegalovirus (CMV) infection is still a major problem in patients who undergo transplantation. Support of the patients’ immunedefenseagainstthevirusisamajor goalintransplantationmedicine.Wehave usedthemurinemodelofCMV(MCMV)to investigate the potential of a cell-based strategy to support the humoral antiviral immune response. Immunocompetent C57BL/6 mice were infected with MCMV, and memory B cells from the immune animals were adoptively transferred into T-cell– and B-cell–deficient RAG-1/ mice. Following MCMV infection, a virusspecific IgG response developed within 4 to 7 days in the recipient animals. Concomitantly, a significant reduction in viral titers and DNA copies in several organs was observed. In addition, the memory B-cell transfer provided long term protection from the lethal course of the infection that is invariably seen in immunodeficient animals. Transfer of memory B cells was also effective in protecting from an already ongoing viral infection, indicating a therapeutic potential of virus-specific memory B cells. T cells were not involved in this process. Our data provide evidence that a cell based strategy to support the humoral immune response can b effective to combat infectious pathogens in severely immunodeficient hosts.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBlood
Brojčani podacivol. 110, br. 9, str. 3472-3479
p-ISSN0006-4971
e-ISSN1528-0020
DOIhttps://doi.org/10.1182/blood-2007-06-095414
URN:NBNurn:nbn:hr:184:500526
Datum objave publikacije2007-11-01
URL dokumentahttp://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-06-095414
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2019-04-04 06:53:26