prikaz prve stranice dokumenta Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells
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Scientific paper - Original scientific paper
Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells
Blood, 110 (2007), 9; 3472-3479. https://doi.org/10.1182/blood-2007-06-095414
Klenovsek, K.; Weisel, F.; Schneider, A.; Appelt, U.; Jonjić, Stipan; Messerle, Martin; Bradel-Tretheway, B.; Winkler, T. H.; Mach, M.

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Klenovsek, K., Weisel, F., Schneider, A., Appelt, U., Jonjić, S., Messerle, M. ... Mach, M. (2007). Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood, 110. (9), 3472-3479. doi: 10.1182/blood-2007-06-095414

Klenovsek, K., et al. "Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells." Blood, vol. 110, no. 9, 2007, pp. 3472-3479. https://doi.org/10.1182/blood-2007-06-095414

Klenovsek, K., F. Weisel, A. Schneider, U. Appelt, Stipan Jonjić, Martin Messerle, B. Bradel Tretheway, T. H. Winkler and M. Mach. "Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells." Blood 110, no. 9 (2007): 3472-3479. https://doi.org/10.1182/blood-2007-06-095414

Klenovsek, K., et al. (2007) 'Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells', Blood, 110(9), pp. 3472-3479. doi: 10.1182/blood-2007-06-095414

Klenovsek K, Weisel F, Schneider A, Appelt U, Jonjić S, Messerle M, and sur.. Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood [Internet]. 2007 November 01 [cited 2024 November 11];110(9):3472-3479. doi: 10.1182/blood-2007-06-095414

K. Klenovsek, et al., "Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells", Blood, vol. 110, no. 9, pp. 3472-3479, November 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:500526. [Accessed: 11 November 2024]

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Metadata
Title (english)Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells
AuthorK. Klenovsek
AuthorF. Weisel
AuthorA. Schneider
AuthorU. Appelt
AuthorStipan Jonjić
AuthorMartin Messerle
AuthorB. Bradel-Tretheway
AuthorT. H. Winkler
AuthorM. Mach
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Severe disease associated with cytomegalovirus (CMV) infection is still a major problem in patients who undergo transplantation. Support of the patients’ immunedefenseagainstthevirusisamajor goalintransplantationmedicine.Wehave usedthemurinemodelofCMV(MCMV)to investigate the potential of a cell-based strategy to support the humoral antiviral immune response. Immunocompetent C57BL/6 mice were infected with MCMV, and memory B cells from the immune animals were adoptively transferred into T-cell– and B-cell–deficient RAG-1/ mice. Following MCMV infection, a virusspecific IgG response developed within 4 to 7 days in the recipient animals. Concomitantly, a significant reduction in viral titers and DNA copies in several organs was observed. In addition, the memory B-cell transfer provided long term protection from the lethal course of the infection that is invariably seen in immunodeficient animals. Transfer of memory B cells was also effective in protecting from an already ongoing viral infection, indicating a therapeutic potential of virus-specific memory B cells. T cells were not involved in this process. Our data provide evidence that a cell based strategy to support the humoral immune response can b effective to combat infectious pathogens in severely immunodeficient hosts.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBlood
Numberingvol. 110, no. 9, pp. 3472-3479
p-ISSN0006-4971
e-ISSN1528-0020
DOIhttps://doi.org/10.1182/blood-2007-06-095414
URN:NBNurn:nbn:hr:184:500526
Publication2007-11-01
Document URLhttp://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-06-095414
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2019-04-04 06:53:26