prikaz prve stranice dokumenta Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
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Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
PLoS Pathogens, 10 (2014), 3; e1004000. https://doi.org/10.1371/journal.ppat.1004000
Zarama, Angela; Pérez-Carmona, Natàlia; Farré, Domènec; Tomić, Adriana; Borst, Eva Maria; Messerle, Martin; Jonjić, Stipan; Engel, Pablo; Angulo, Ana

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Zarama, A., Pérez Carmona, N., Farré, D., Tomić, A., Borst, E. M., Messerle, M. ... Angulo, A. (2014). Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control. PLoS Pathogens, 10. (3). doi: 10.1371/journal.ppat.1004000

Zarama, Angela, et al. "Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control." PLoS Pathogens, vol. 10, br. 3, 2014. https://doi.org/10.1371/journal.ppat.1004000

Zarama, Angela, Natàlia Pérez Carmona, Domènec Farré, Adriana Tomić, Eva Maria Borst, Martin Messerle, Stipan Jonjić, Pablo Engel i Ana Angulo. "Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control." PLoS Pathogens 10, br. 3 (2014). https://doi.org/10.1371/journal.ppat.1004000

Zarama, A., et al. (2014) 'Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control', PLoS Pathogens, 10(3). doi: 10.1371/journal.ppat.1004000

Zarama A, Pérez Carmona N, Farré D, Tomić A, Borst EM, Messerle M, i sur.. Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control. PLoS Pathogens [Internet]. 13.03.2014. [pristupljeno 27.12.2024.];10(3). doi: 10.1371/journal.ppat.1004000

A. Zarama, et al., "Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control", PLoS Pathogens, vol. 10, br. 3, Ožujak 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:690610. [Citirano: 27.12.2024.]

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Naslov (engleski)Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
AutorAngela Zarama
AutorNatàlia Pérez-Carmona
AutorDomènec Farré
AutorAdriana Tomić
AutorEva Maria Borst
AutorMartin Messerle
AutorStipan Jonjić
AutorPablo Engel
AutorAna Angulo
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Cytomegalovirus (CMV) has developed diverse tactics to elude the host immune response and guarantee its survival. The signalling lymphocyte-activation molecules (SLAM) family of receptors encompasses a number of adhesion molecules expressed on the surface of leukocytes that play critical roles in both innate and adaptive immunity. In this study, we report that murine CMV drastically reduces the expression of several SLAM family receptors at the cell surface of infected macrophages, most likely as part of its immunoevasion mechanisms. We have identified a murine CMV gene product (m154) that downregulates CD48, a SLAM family member that functions as a ligand of CD244, a molecule involved in the regulation of natural killer (NK) and cytotoxic T cell functions. We show that during infection, m154 targets CD48 for degradation. Moreover, this viral protein contributes to increased MCMV growth during acute infection in the mouse by protecting against NK cell mediated surveillance. These findings are important for better understanding CMV pathogenesis, and provide a novel example of host innate immune subversion by CMV.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS Pathogens
Brojčani podacivol. 10, br. 3, e1004000
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1004000
URN:NBNurn:nbn:hr:184:690610
Datum objave publikacije2014-03-13
ProjektŠifra: 256686
Naziv (engleski): Upgrading the capacities for research in translational medicine at the Faculty of Medicine University of Rijeka
Kratica: TRANSMEDRI
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
URL dokumentahttp://dx.plos.org/10.1371/journal.ppat.1004000
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-02-25 23:15:02