prikaz prve stranice dokumenta Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
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Scientific paper - Original scientific paper
Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
PLoS Pathogens, 10 (2014), 3; e1004000. https://doi.org/10.1371/journal.ppat.1004000
Zarama, Angela; Pérez-Carmona, Natàlia; Farré, Domènec; Tomić, Adriana; Borst, Eva Maria; Messerle, Martin; Jonjić, Stipan; Engel, Pablo; Angulo, Ana

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Zarama, A., Pérez Carmona, N., Farré, D., Tomić, A., Borst, E. M., Messerle, M. ... Angulo, A. (2014). Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control. PLoS Pathogens, 10. (3). doi: 10.1371/journal.ppat.1004000

Zarama, Angela, et al. "Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control." PLoS Pathogens, vol. 10, no. 3, 2014. https://doi.org/10.1371/journal.ppat.1004000

Zarama, Angela, Natàlia Pérez Carmona, Domènec Farré, Adriana Tomić, Eva Maria Borst, Martin Messerle, Stipan Jonjić, Pablo Engel and Ana Angulo. "Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control." PLoS Pathogens 10, no. 3 (2014). https://doi.org/10.1371/journal.ppat.1004000

Zarama, A., et al. (2014) 'Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control', PLoS Pathogens, 10(3). doi: 10.1371/journal.ppat.1004000

Zarama A, Pérez Carmona N, Farré D, Tomić A, Borst EM, Messerle M, and sur.. Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control. PLoS Pathogens [Internet]. 2014 March 13 [cited 2024 December 27];10(3). doi: 10.1371/journal.ppat.1004000

A. Zarama, et al., "Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control", PLoS Pathogens, vol. 10, no. 3, March 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:690610. [Accessed: 27 December 2024]

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Metadata
Title (english)Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
AuthorAngela Zarama
AuthorNatàlia Pérez-Carmona
AuthorDomènec Farré
AuthorAdriana Tomić
AuthorEva Maria Borst
AuthorMartin Messerle
AuthorStipan Jonjić
AuthorPablo Engel
AuthorAna Angulo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegalovirus (CMV) has developed diverse tactics to elude the host immune response and guarantee its survival. The signalling lymphocyte-activation molecules (SLAM) family of receptors encompasses a number of adhesion molecules expressed on the surface of leukocytes that play critical roles in both innate and adaptive immunity. In this study, we report that murine CMV drastically reduces the expression of several SLAM family receptors at the cell surface of infected macrophages, most likely as part of its immunoevasion mechanisms. We have identified a murine CMV gene product (m154) that downregulates CD48, a SLAM family member that functions as a ligand of CD244, a molecule involved in the regulation of natural killer (NK) and cytotoxic T cell functions. We show that during infection, m154 targets CD48 for degradation. Moreover, this viral protein contributes to increased MCMV growth during acute infection in the mouse by protecting against NK cell mediated surveillance. These findings are important for better understanding CMV pathogenesis, and provide a novel example of host innate immune subversion by CMV.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLoS Pathogens
Numberingvol. 10, no. 3, e1004000
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1004000
URN:NBNurn:nbn:hr:184:690610
Publication2014-03-13
ProjectNumber: 256686
Title (english): Upgrading the capacities for research in translational medicine at the Faculty of Medicine University of Rijeka
Acronym: TRANSMEDRI
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://dx.plos.org/10.1371/journal.ppat.1004000
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-02-25 23:15:02