prikaz prve stranice dokumenta Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection
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Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection
Journal of General Virology, 74 (1993), 10; 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215
Pavić, Ivica; Polić, Bojan; Crnković, Irena; Lučin, Pero; Jonjić, Stipan; Koszinowski, U. H.

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Pavić, I., Polić, B., Crnković, I., Lučin, P., Jonjić, S. i Koszinowski, U. H. (1993). Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection. Journal of General Virology, 74. (10), 2215-2223. doi: 10.1099/0022-1317-74-10-2215

Pavić, Ivica, et al. "Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection." Journal of General Virology, vol. 74, br. 10, 1993, str. 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215

Pavić, Ivica, Bojan Polić, Irena Crnković, Pero Lučin, Stipan Jonjić i U. H. Koszinowski. "Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection." Journal of General Virology 74, br. 10 (1993): 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215

Pavić, I., et al. (1993) 'Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection', Journal of General Virology, 74(10), str. 2215-2223. doi: 10.1099/0022-1317-74-10-2215

Pavić I, Polić B, Crnković I, Lučin P, Jonjić S, Koszinowski UH. Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection. Journal of General Virology [Internet]. 01.10.1993. [pristupljeno 04.12.2024.];74(10):2215-2223. doi: 10.1099/0022-1317-74-10-2215

I. Pavić, B. Polić, I. Crnković, P. Lučin, S. Jonjić i U. H. Koszinowski, "Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection", Journal of General Virology, vol. 74, br. 10, str. 2215-2223, Listopad 1993. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:611848. [Citirano: 04.12.2024.]

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Naslov (engleski)Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection
AutorIvica Pavić
AutorBojan Polić
AutorIrena Crnković
AutorPero Lučin
AutorStipan Jonjić
AutorU. H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Interferon gamma (IFN gamma) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission. Because IFN gamma cannot be responsible for all cytokine effects during recovery from MCMV infection we have now tested the potential participation of tumour necrosis factor alpha (TNF alpha) in the antiviral defence. Neutralization of endogenous TNF alpha abolished the antiviral activity of CD4 T cells in immunocompetent as well as in CD8 subset-deficient mice. These data suggest that the antiviral effect of the CD4 subset requires the presence of at least two cytokines, namely IFN gamma and TNF alpha. Depletion of endogenous TNF alpha in adoptive cell transfer recipients diminished the antiviral function of CD8 T lymphocytes suggesting that TNF alpha also participates in CD8 T cell effector functions. Furthermore, endogenous cytokines were found to be required for survival after infection with lethal doses of MCMV, whereas immunotherapy with recombinant TNF alpha and IFN gamma could not limit virus replication in vivo. The results suggest that, similar to IFN gamma, TNF alpha is an integral part of the protective mechanisms involved in cytomegalovirus clearance.
Ključne riječi (hrvatski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of General Virology
Brojčani podacivol. 74, br. 10, str. 2215-2223
p-ISSN0022-1317
e-ISSN1465-2099
DOIhttps://doi.org/10.1099/0022-1317-74-10-2215
URN:NBNurn:nbn:hr:184:611848
Datum objave publikacije1993-10-01
URL dokumentahttp://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-10-2215
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2018-11-29 22:10:14